ArticleIrish veterinary journal2025
The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing.
Article in Irish veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Integrating whole-genome sequencing and epidemiology to characterise Mycobacterium bovis transmission in Ireland: a proof of concept.Irish veterinary journal · 2025Article
- SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data.Access microbiology · 2025Article
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Authors and funding
21 authors.
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Abstract
backgroundBovine tuberculosis (bTB), caused primarily by Mycobacterium bovis, remains a major challenge across the island of Ireland. Despite decades of an eradication programme that encompasses cattle testing, movement restrictions, and badger culling, bTB prevalence has increased in recent years. The epidemiology of bTB is complex, with inter-species (e.g. badger-cattle) and intra-species (e.g. cattle-cattle) transmission of infection. This study utilised whole-genome sequencing (WGS) to investigate the genetic diversity and spatial distribution of M. bovis across the island of Ireland as a route to help elucidate transmission of infection.
resultsA total of 5,875 M. bovis isolates from cattle and badgers were analysed to identify strain diversity, geographic clustering, and patterns of strain sharing within and between host species. Our findings reveal significant regional variation in strain distribution, with certain clades predominantly confined to specific regions, while others are more widely dispersed. Strong genetic similarities between cattle and badger isolates support the role of badgers as infection reservoirs. Furthermore, a subset of herds contained multi-strain infections and amongst these herds there were 'controlled finishing units' (CFUs), where infection was more likely driven by inward cattle movements than local transmission.
conclusionsBy integrating phylogenetic analysis with spatial mapping and cattle movement data, this study provides new insights into M. bovis transmission pathways and highlights the value of WGS in refining Ireland's bTB control strategies.
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