Evidence map›Paper›PMID 41340137›Full record

ArticleBiochemistry2025

Small Molecule Modulation of APOBEC3A-Catalyzed Cytosine Deamination in CCG Repeat Deoxyribonucleic Acid via Stabilization of Hairpin Structures.

Luyan Zhang, Tomonori Shibata, Asako Murata, Yusuke Takashima, Kazuhiko Nakatani

Abstract read
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In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luyan ZhangDepartment of Regulatory Bioorganic Chemistry, SANKEN, The University of Osaka, Mihogaoka 8-1, Ibaraki, Osaka 567-0047. JAPAN.
Tomonori ShibataDepartment of Regulatory Bioorganic Chemistry, SANKEN, The University of Osaka, Mihogaoka 8-1, Ibaraki, Osaka 567-0047. JAPAN.ORCID 0000-0002-3653-0383
Asako MurataDepartment of Regulatory Bioorganic Chemistry, SANKEN, The University of Osaka, Mihogaoka 8-1, Ibaraki, Osaka 567-0047. JAPAN.ORCID 0000-0003-2073-7272
Yusuke TakashimaDepartment of Regulatory Bioorganic Chemistry, SANKEN, The University of Osaka, Mihogaoka 8-1, Ibaraki, Osaka 567-0047. JAPAN.ORCID 0000-0002-6096-2805
Kazuhiko NakataniDepartment of Regulatory Bioorganic Chemistry, SANKEN, The University of Osaka, Mihogaoka 8-1, Ibaraki, Osaka 567-0047. JAPAN.ORCID 0000-0002-1705-5265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeat expansions in the genome are associated with numerous genetic diseases. The instability of repeat sequences is driven in part by slipped-out structures, such as hairpins. APOBEC3A (A3A), a cytosine deaminase, preferentially targets single-stranded DNA, including repeat regions capable of forming such secondary structures. In this study, we investigated how small molecules that selectively bind C-C mismatches in CCG hairpin repeats modulate A3A-mediated deamination. Using model oligonucleotides containing (CCG)

Indexed as

Cytidine DeaminaseCytosineDNAProteinsTrinucleotide RepeatsDeaminationHumansNucleic Acid ConformationAPOBEC3A protein, humanCytidine DeaminaseCytosineDNAProteins

Identifiers

PMID41340137
PMCPMC12713718

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.