ArticleBMC gastroenterology2025
Endoscopic Histoacryl injection with clips is associated with lower early rebleeding compared to Histoacryl injection alone in the treatment of gastric varices.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Gastric varices: a contemporary review of vascular anatomy and therapeutic strategies.BMJ open gastroenterology · 2026Review
- Effect of fresh-frozen plasma transfusion on intraventricular hemorrhage risk in preterm infants with prolonged APTT: a target trial emulation with causal forest analysis.Frontiers in neuroscience · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether Histoacryl injection with clips is superior to Histoacryl injection alone in terms of efficacy and safety.
methodsPatients with gastric varices who were admitted to our Department and received Histoacryl injection or Histoacryl injection with clips between January 2019 and December 2024 were enrolled. Patients were followed up, and data of patients were collected. Propensity score matching was used to match the variables between the two groups. Post-operative bleeding and adverse events between the two groups were compared.
resultsA total of 148 patients with gastric varices were enrolled in the study, 139 patients completed follow up and were included in the final analysis, among them, 116 patients in the Histoacryl injection alone group and 23 patients in the clip-assisted Histoacryl injection group. After propensity score matching, 92 patients were successfully matched, 23 patients in the clip-assisted Histoacryl injection group and 69 patients in the Histoacryl injection alone group. There were significantly more early post-operative bleeding episodes in the Histoacryl injection alone group than the clip-assisted Histoacryl injection group, there was no significant difference in terms of late post-operative bleeding, as well as abdominal pain and fever.
conclusionsHistoacryl injection with clips has lower early post-operative bleeding rate, without more adverse events. Histoacryl injection with clips may be preferred as an endoscopic treatment, especially for patients with larger gastric varices.
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