ArticleBMC sports science, medicine & rehabilitation2025
Effects of high and moderate intensity exercise training on sex hormones and testicular damage induced by cisplatin in rats.
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCisplatin, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis in the testes, reduces sex hormones (testosterone, LH, FSH), and impairs sperm quality and structure. MICT typically increases testicular function and hormone levels, whereas HIIT may negatively affect steroidogenesis and the HPG axis, although findings vary. This study investigates the effects of HIIT and MICT on reducing cisplatin-induced testicular damage in rat, providing a noninvasive approach to preserve fertility for chemotherapy patients.
methodsIn this randomized controlled experimental study twenty-four eight-week-old Sprague Dawley rats (200–240 g) were randomly assigned into four groups (n = 6 per group): healthy control (HC), cisplatin control (CC), Cisplatin-moderate intensity continuous training (C-MICT) and Cisplatin-high intensity interval training (C-HIIT). Except for the HC group, in other groups, 5 mg/kg of cisplatin was injected intraperitoneally as a single dose. HIIT involved alternating high-speed intervals (54 m/min, 30s) with recovery (40 m/min, 3 min), progressing to 20 intervals per session; MICT consisted of continuous running at 27 m/min for up to 60 min, both performed 6 days/week. Sex hormones, histological parameters of testicular tissue, sperm parameters and oxidant/lipid-peroxide were measured.
resultsCisplatin injection caused a significant decrease in LH, FSH, and testosterone compared to the HC group (P ≤ 0.0001). C-MICT and C-HIIT significantly increased LH (P ≤ 0.0001), FSH (P = 0.001), and testosterone (P ≤ 0.003) compared to CC groups. C-HIIT significantly increased LH (P ≤ 0.001) and testosterone (P ≤ 0.0001) compared to C-MICT groups. C-HIIT and C-MICT significantly improve sperm parameters such as sperm count, sperm morphology and progressively motile sperm, testicular weight and volume, lipid peroxide, and antioxidant level (P ≤ 0.05) and reverse the cisplatin injection effects. CONCLUSION(S): HIIT and MICT both effectively mitigate cisplatin-induced testicular damage by improving sex hormone levels, sperm quality, and histological parameters. HIIT demonstrated comparable or superior benefits to MICT in certain outcomes, suggesting that exercise training may serve as a valuable non-pharmacological strategy to preserve testicular function during chemotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.