ArticleJournal of translational medicine2025
Social determinants of health and life expectancy in US adults.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Perceptions of poverty and associated factors among first- and second-year nursing students: a cross-sectional study.Frontiers in public health · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIndividual unfavorable social determinants of health (SDoH) negatively affect health outcomes, yet the combined impact of multiple SDoH on life expectancy is not well understood.
methodsWe analyzed data from a nationally representative sample of US adults aged ≥18 years in NHANES (1999–2018) to examine associations between unfavorable SDoH—both individually and in combination—and life expectancy.
resultsAmong 45,516 participants (mean age 47.7 years; 51.4% women) with a median follow-up of 9.4 years, 6,164 deaths occurred. Four key SDoH—employment, family income, education, and marital status—were individually associated with shorter life expectancy at age 50: unemployment (−4.2 years, 95% CI 3.9–4.6), low income (−3.5, 3.1–3.9), low education (−3.1, 2.7–3.4), and unmarried status (−2.4, 2.1–2.8). Among 16 combined SDoH profiles, participants who were unemployed, low-educated, and unmarried lost 10.8 years compared with the most favorable profile. Notably, education had the largest individual impact, but its effect diminished when combined with other adverse SDoH; well-educated individuals with multiple unfavorable SDoH lost more life years than less-educated counterparts (7.2 vs. 4.9 years).
conclusionsIn this nationally representative cohort, four key SDoH strongly influenced life expectancy. Multiple adverse SDoH had additive effects, and the impact of education was context-dependent, emphasizing the importance of considering combined social risk in public health strategies.
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