Observational studyBMC neurology2025
Carotid web ultrasonography and its associations with ischemic stroke: a preliminary observational study.
Observational study in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07495241 (Prevalence of Carotid Web in Youth Assessed by Duplex Sonography), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Prevalence of Carotid Web in Youth Assessed by Duplex Sonography: a Cross-Sectional Study
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8 authors.
Funding
Abstract
backgroundThis study aims to characterize the carotid web (CW) via Ultrasonography and explore its structural correlations with cerebral ischemic stroke (CIS).
methodsWe retrospectively reviewed 11,656 patients hospitalized in the neurology department of our center who underwent carotid ultrasonography at our center between January 2018 and December 2024. Patients were included if they had CTA within 2 weeks of ultrasound. We calculated CW incidence with 95% confidence intervals (CIs) and compared baseline characteristics, lipid profiles, and ultrasonic features (length, thickness, web angle, atherosclerotic plaque, thrombus) between patients with and without CIS.
resultsA total of 138 patients with 140 carotid webs (CWs) were identified by consensus between CTA and ultrasound, including 2 cases with bilateral CWs. The incidence of CW was 2.9% (95% CI: 2.5%–3.4%), with a mean age of 60.6±12.7 years and 66.4% male (n = 93). Fifty-four patients with 54 CWs and cerebral ischemic strokes were assigned to the CIS group, while 84 patients with 86 asymptomatic CWs were in the non-CIS group. CIS patients were younger and had lower rates of hypertension, hyperlipidemia, and coronary artery disease (P＜0.01,P = 0.002, P = 0.037), along with decreased levels of cholesterol (P= 0.005), triglyceride (P = 0.029), and low-density lipoprotein (P = 0.002). Ipsilateral middle cerebral artery severe stenosis or occlusion was significantly more frequent in the CIS group (20.4% vs. 1.2%, P<0.01). CWs in the CIS group were longer (8.0 vs. 5.9 mm, P=0.002) and thicker (1.2 vs. 1.0 mm, P=0.001) but had a smaller angle (42.5° vs. 59.0°, P=0.002). Thrombus association was more common in the CIS group (29.6% vs. 3.5%, P<0.01), while atherosclerotic plaque (35.2% vs. 54.7%, P = 0.025) and ≥50% carotid stenosis (18.5% vs. 39.5%, P = 0.009) were less frequent.
conclusionsPatients with CW complicated by CIS were younger, exhibited longer and thicker CWs, smaller web angles, and a significantly higher prevalence of thrombus compared to the asymptomatic patients.
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