Evidence map›Paper›PMID 41340008›Full record

Trial reportSurgical endoscopy2026

Intraoperative neuromonitoring reduces vocal cord injury in open thyroid cancer surgery: results from a randomized controlled trial.

Yunchao Xin, Yanbin Liu, Yachao Liu, Qi Xie, Chuan Liu, Guogang Xu, Xiaoling Shang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunchao XinOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Yanbin LiuOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Yachao LiuOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Qi XieOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Chuan LiuOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Guogang XuOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China.
Xiaoling ShangOtolaryngology-Head and Neck Surgery Department, The First Affiliated Hospital of Hebei North University, No.12 Changqing Road, Qiaoxi, Zhangjiakou, 075000, Hebei, China. XXL030100@126.COM.ORCID 0009-0005-6137-6815

Funding

Health and Family Planning Commission of Gansu 20241209Research on Individualized Surgical Treatment Strategies for Thyroid Tumors, Jihua Preface and Reply 【2020】397
6 · The paper itself

Abstract

backgroundIntraoperative neuromonitoring (IONM) has been increasingly used in thyroid surgery, yet its clinical value remains controversial.

objectivesThis randomized controlled trial aimed to evaluate the efficacy and safety of IONM in thyroid cancer surgery.

methodsThe standardized four-step monitoring protocol was used in the IONM group. Primary endpoints included RLN injury rates and postoperative voice function recovery. Secondary endpoints included surgical parameters (operation time, blood loss), complication rates, and oncological outcomes. Voice function was assessed using VHI-10 scoring and maximum phonation time (MPT). Patients were followed up for a median of 6 months.

resultsThe IONM group demonstrated significantly lower rates of temporary vocal cord paralysis (2.0% vs 10.0%, P = 0.038) and higher nerve identification rates (100% vs 96.0%) compared to the control group. Voice function recovery was notably faster in the IONM group, with smaller changes in VHI-10 scores (Δ = 4.2 ± 1.5 vs 7.6 ± 2.1, P < 0.001) and shorter MPT recovery time (14.2 ± 3.5 vs 25.6 ± 5.2 days, P < 0.001). Although operation time was longer in the IONM group (125.6 ± 18.3 vs 108.4 ± 15.7 min, P < 0.001), no significant differences were found in blood loss (45.3 ± 12.6 ml vs 48.7 ± 13.2 ml, P = 0.183), complication rates, or oncological outcomes between the groups.

conclusionIONM technology greatly lowers the risk of temporary recurrent laryngeal nerve injury and speeds up voice function recovery in thyroid cancer surgery. Although operation times are slightly extended, the technique is safe and preserves oncological integrity.

Indexed as

Intraoperative Neurophysiological MonitoringMonitoring, IntraoperativePostoperative ComplicationsRecurrent Laryngeal Nerve InjuriesThyroidectomyThyroid NeoplasmsVocal Cord ParalysisAdultAgedFemaleHumansMaleMiddle AgedOperative TimeRecovery of FunctionTreatment OutcomeIntraoperative neuromonitoringLaryngeal nerve injuriesProspective studiesThyroidectomyThyroid neoplasmsVocal cord paralysis

Identifiers

PMID41340008
PMCPMC12881059

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.