ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
Plasmid-mediated carbapenem resistance: global dissemination patterns and replicon-gene associations.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs.mSphere · 2026Review
- Global Analysis of the Co-Occurrence of Antimicrobial and Metal Resistance Genes in Bacterial Genomes From Dairy-Isolated Pathogens.Environmental microbiology · 2026Article
- Multi-replicon Architecture Drives the Global Accumulation of Resistance to Antimicrobials, Biocides, and Metals in IncF and IncH Plasmids.Current microbiology · 2026Article
- Large-scale plasmidome and carbapenem mobilome analysis reveals a mechanistic duality: high-power specialists and structural generalists mobile genetic elements.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Carbapenem resistance, especially among members of the Enterobacterales order, poses a serious challenge to public health today. This scenario is further intensified by the dissemination of plasmids carrying carbapenemase-encoding genes, which complicates the control of multidrug-resistant organisms. In this study, we analyzed plasmid sequences and metadata available in the PLSDB database to investigate the global dissemination of carbapenem resistance genes, examining the taxonomy of the isolates, the source of isolation, and the geographic location. We aimed to identify statistically significant associations between plasmid replicons and carbapenemase genes to better elucidate the patterns of gene dissemination. Significant correlations were observed between the IncL, ColKP3, IncM2, IncC, IncFII(pHN7A8), IncR and IncFII replicons and the blaOXA−48, blaOXA−181, blaIMP−1, blaNDM−4, blaKPC−2, blaKPC−2 and blaNDM−5 genes, respectively. Interestingly, we identified a negative association between the blaKPC−2 gene and the IncL and IncX3 replicons, suggesting a possible exclusion or incompatibility mechanism that remains to be elucidated. These findings underscore the complexity of replicon-gene interactions, whose understanding is crucial for the development of more precise and effective interventions, while also highlighting the role of plasmid replicons in shaping the global epidemiology of carbapenem resistance. Additional experimental studies are needed to accurately validate these associations and unravel the molecular mechanisms underlying these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.