Evidence map›Paper›PMID 41339976›Full record

ArticleDiscover oncology2025

The role of cranial radiotherapy in managing neurological symptoms of brain metastases from pulmonary choriocarcinoma: a case report and literature review.

Haozheng Lu, Aimin Jiang, Xijun Liu, Peng Zhang, Jinming Yu, Dawei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haozheng Lu *Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, Jinan, 250117, Shandong Province, People's Republic of China.
Aimin Jiang *Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, Jinan, 250117, Shandong Province, People's Republic of China.
Xijun LiuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, 250117, Jinan,Shandong Province, People's Republic of China.
Peng ZhangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, 250117, Jinan,Shandong Province, People's Republic of China.
Jinming YuShandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, Jinan, 250117, Shandong Province, People's Republic of China. sdyujinming@126.com.
Dawei ChenShandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No.440 Jiyan Road, Jinan, 250117, Shandong Province, People's Republic of China. dave0505@yeah.net.

Funding

Collaborative Academic Innovation Project of Shandong Cancer Hospital GF001National Natural Science Foundation of China 82030082National Natural Science Foundation of China 82172676National Natural Science Foundation of China 82373217Natural Science Foundation of Shandong ZR2021YQ52Natural Science Foundation of Shandong ZR2023ZD26Natural Science Foundation of Shandong ZR2024JQ032Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0519900Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0519902Postdoctoral Innovation Program of Shandong Province SDCX-ZG-202502079
6 · The paper itself

Abstract

backgroundPrimary pulmonary choriocarcinoma (PPC) is a rare and highly malignant germ cell tumor. This tumor is prone to brain metastasis, severely affecting the quality of life of patients. The optimal treatment regimen for PPC brain metastasis remains undetermined, and there is a lack of support for the efficacy of radiotherapy in improving symptoms and the appropriate radiation exposure dose for such patients. CASE DESCRIPTION: We report a case of a 73-year-old Asian male with PPC and brain metastasis, who was admitted due to numbness and discomfort in his right limbs. Since the patient and his family initially refused chemotherapy due to his poor physical condition, he was first subjected to cranial radiotherapy. The patient received a total dose of 37.5 Gy in 15 fractions using intensity-modulated radiation therapy (IMRT), followed by an additional 8 Gy with CyberKnife. He demonstrated marked sensitivity to radiotherapy, with strong tolerance and compliance. Compared to admission, his neurological symptoms improved significantly, and tumor progression was effectively controlled.

conclusionsOur findings suggest that localized brain radiotherapy can significantly enhance the quality of life in patients with PPC and brain metastasis, with minimal adverse effects.

Indexed as

Brain metastasisCase reportLiterature reviewPulmonary choriocarcinomaRadiotherapy

Identifiers

PMID41339976
PMCPMC12779832

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.