Evidence map›Paper›PMID 41339956›Full record

ArticleClinical oral investigations2025

Drug interaction between non-steroidal anti-inflammatory drugs and warfarin: a cross-sectional study.

Widla Emanuella Pereira Barreto Garcez, Alex Junio Silva da Cruz, Jennifer Reis-Oliveira, Jacqueline Silva Santos, Maria Auxiliadora Parreiras Martins, Ana Cristina Borges-Oliveira, Mauro Henrique Nogueira Guimarães Abreu

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Widla Emanuella Pereira Barreto GarcezDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil. garcezwidla@gmail.com.ORCID 0000-0003-0374-0680
Alex Junio Silva da CruzDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0003-1905-4124
Jennifer Reis-OliveiraDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0002-6040-8935
Jacqueline Silva SantosDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0003-0572-4668
Maria Auxiliadora Parreiras MartinsDepartment of Pharmaceutical Products, School of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0002-5211-411X
Ana Cristina Borges-OliveiraDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0003-3364-4024
Mauro Henrique Nogueira Guimarães AbreuDepartment of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627 - Pampulha, Belo Horizonte, 31270-800, MG, Brazil.ORCID 0000-0001-8794-5725

Funding

Conselho Nacional de Pesquisa (CNPq) Fellowship nº: 305806/2023-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais Finance Code APQ-00711-23
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the frequency, and municipal and individual demographic factors, such as sex and age, associated with potential drug-drug interaction (PDDI) between warfarin and non-steroidal anti-inflammatory drugs (NSAIDs) prescribed by dentists in the state of Minas Gerais (MG), Southeast Brazil. MATERIALS AND

methodsA secondary data analysis of a cross-sectional study was conducted using data from the Integrated Pharmaceutical Care Management System (Sigaf) in MG, Brazil, from January to December 2021. IBM SPSS, version 26.0, and Hierarchical Linear and Nonlinear Modelling, version 7.0, were used for data analysis. Poisson Regression was used to estimate the prevalence ratio of potential drug interactions between individual variables.

resultsData were collected and analyzed from individuals residing in 678 out of 853 municipalities in MG (79.5%). In 2021, 14,474 individuals received warfarin and, among those, 122 received a dental prescription for NSAID. The PDDI occurred in 60 patients. In the multivariate Poisson regression model, increasing age was significantly associated with a lower prevalence of PDDI (p < 0.001).

conclusionsThe frequency of PDDI among warfarin users was low in 2021. However, among those who received warfarin and dental prescriptions for NSAIDs, the occurrence of PDDI was significant. Furthermore, patient age was found to be an influential factor in PDDI. CLINICAL RELEVANCE: These findings guide dental prescribers in managing drug interactions by either avoiding the combination or monitoring for early detection when its administration is necessary, impacting the patient’s oral and general health quality.

Indexed as

AnticoagulantsAnti-Inflammatory Agents, Non-SteroidalWarfarinAdultAgedBrazilCross-Sectional StudiesDrug InteractionsFemaleHumansMaleMiddle AgedAnticoagulantsAnti-Inflammatory Agents, Non-SteroidalWarfarinDental careDrug interactionsPatient safetyPolypharmacySocioeconomic factors

Identifiers

PMID41339956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.