Trial reportCritical care (London, England)2025
Influence of ventilatory settings on pendelluft and expiratory muscle activity in hypoxemic patients resuming spontaneous breathing.
Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Clinical Application of Electrical Impedance Tomography in Emergency and Critical Care Medicine.Journal of clinical medicine · 2026Review
- Protective Ventilation During Controlled and Partial Ventilatory Support in ARDS: Clinical-Physiological Background and Monitoring.Journal of clinical medicine · 2026Review
- Diagnostic accuracy and cost-efficiency of ChatGPT in EIT-based pendelluft detection for mechanically ventilated patients: a multicenter study.Respiratory research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundPendelluft and expiratory muscle activity during spontaneous breathing should be minimized to reduce potential harmful effects. This study aimed to describe pendelluft and expiratory muscle activity in hypoxemic patients recovering spontaneous breathing after ≥ 72 h of lung-protective, fully controlled mechanical ventilation (MV) and assess the effect of pressure support ventilation (PSV) and positive end-expiratory pressure (PEEP).
methodsA physiological, randomized crossover study was conducted in hypoxemic patients receiving three levels of PSV: 5, 10, and 15 cmH₂O, and two PEEP levels: based on electrical impedance tomography before spontaneous breathing (PEEP
resultsFifteen patients were enrolled (mean PaO
conclusionsIn patients with ARDS transitioning to spontaneous breathing, increasing PS reduces pendelluft and expiratory muscle activity. Higher PEEP can decrease pendelluft, but its effect can be counteracted by increased expiratory activity.
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Registered trials
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