Evidence map›Paper›PMID 41339905›Full record

ArticleJournal of ovarian research2025

Deciphering the molecular landscape of NMDAR-E associated ovarian teratomas: a Multi-Omics approach.

Lingwei Ma, Xinmeng Sun, Shaohua Zhang, Yinping Xiao, Haiyun Guan, Rongmin Wang, Zhijing Tang, Wei Zhang, Hexia Xia

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In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lingwei Ma *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Xinmeng Sun *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Shaohua Zhang *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Yinping XiaoDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China.
Haiyun GuanDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Rongmin WangDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Zhijing TangDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China.
Wei ZhangDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China. zhangwei623@hotmail.com.
Hexia XiaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, 200011, China. xhx0101@hotmail.com.

Funding

Shanghai Pujiang Program 21PJD006
6 · The paper itself

Abstract

backgroundAnti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E) is an autoimmune disorder often associated with ovarian teratomas. It involves antibodies against the neuronal NMDAr1 subunits of NR1, but the pathogenesis and molecular mechanisms are not fully understood. To identify significantly differentially expressed genes and proteins and investigate the intricate molecular regulatory network underlying anti-NMDA receptor encephalitis (NMDAR-E) associated with ovarian teratomas.

methodsThis retrospective study analyzed ovarian teratoma samples from patients with and without NMDAR-E. RNA sequencing and iTRAQ coupled LC-MS/MS analysis were used for gene and protein expression profiling. qPCR and western blotting were used to validate the gene and protein expression.

resultsWe identified 2524 significantly differentially expressed genes and 34 proteins. The changes were notable at the mRNA and protein levels in ovarian teratomas associated with NMDAR-E. Functional enrichment analysis highlighted the extracellular matrix and immune activation pathways. Key genes and proteins involved in ferroptosis and immune activation, including SLC40A1, GGH, FKBP11, CCDC80, and ANK3, showed significant expression differences.

conclusionsOur findings provide preliminary insights into the pathophysiology of NMDAR-E associated with ovarian teratomas. These results may generate hypotheses for future mechanistic studies, and the candidate biomarkers identified warrant further validation before clinical translation.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisOvarian NeoplasmsTeratomaFemaleGene Expression ProfilingHumansMultiomicsProteomicsReceptors, N-Methyl-D-AspartateRetrospective StudiesReceptors, N-Methyl-D-AspartateAnti-N-methyl-D-aspartate receptor encephalitisFerroptosisOvarian teratomaProteomicsTranscriptomics

Identifiers

PMID41339905
PMCPMC12676869

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