Evidence map›Paper›PMID 41339861›Full record

ReviewNature structural & molecular biology2025

Gene regulation through exon junction complex modularity.

Elizabeth T Abshire, Lynne E Maquat

Abstract readReview
In one paragraph

Review in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth T AbshireDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-2019-3044
Lynne E MaquatDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. lynne_maquat@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-2789-2075

Funding

Regulation of exon junction complex composition and assemblyK99GM152790 · NIGMS · UNIVERSITY OF ROCHESTER · PI ABSHIRE, ELIZABETH TENLEY · 2024 to 2025
$250k
NIGMS NIH HHS K99 GM152790
6 · The paper itself

Abstract

The exon junction complex (EJC) begins to assemble on the spliceosome, which deposits EJCs upstream of most exon-exon junctions during pre-messenger RNA (mRNA) splicing. EJCs acquire additional alternative modules that define heterogeneous EJCs during pre-mRNA processing to mRNA in the nucleus and after mRNA export into the cytoplasm. In this Review, we discuss the mechanisms of EJC formation, the many roles of the EJC in pre-mRNA and mRNA regulation and how these roles are influenced by EJC composition.

Indexed as

ExonsGene Expression RegulationRNA SplicingSpliceosomesAnimalsHumansRNA, MessengerRNA PrecursorsRNA, MessengerRNA Precursors

Identifiers

PMID41339861
PMCPMC13255255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.