ArticleMolecular psychiatry2026
Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.
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Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
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Who cites it
5 citing papers in PubMed.
- Hippocampal subfield radiomics improves identification of in-hospital aggressive behavior in schizophrenia: an interpretable machine-learning study.BMC psychiatry · 2026Article
- Emotion recognition misclassification patterns in individuals with psychotic spectrum disorders and history of interpersonal aggression.Schizophrenia (Heidelberg, Germany) · 2026Article
- Data-driven schizophrenia subtyping via brain atrophy trajectories and functional connectivity.Translational psychiatry · 2026Article
- Corticolimbic Structural Deficits in Violent Patients with Schizophrenia.Brain sciences · 2025Article
- A Systematic Review of the Effects of EEG Neurofeedback on Patients with Schizophrenia.Journal of personalized medicine · 2024Review
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Authors and funding
80 authors.
Jelle LamsmaDepartment of Criminology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. j.lamsma@vu.nl.
Adrian RaineDepartment of Criminology, University of Pennsylvania, Philadelphia, PA, USA.
Seyed M KiaDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-7128-814X
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-0482-8759
Dominic AroldDivision of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Dresden, Germany.
Nerisa BanajLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-6317-8549
Annarita BaroneDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Katharina BroschDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0526-8095
Rachel BrouwerDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-7466-1544
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0001-7057-3494
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9058-0747
Qian H ChewDepartment of Research, Institute of Mental Health, Singapore, Singapore.
Sunah ChoiDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.ORCID http://orcid.org/0000-0001-5666-3485
Young-Chul ChungDepartment of Psychiatry, Jeonbuk National University, Jeonju, South Korea.ORCID http://orcid.org/0000-0001-9491-1822
Mariateresa CiccarelliDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Derin CobiaDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0000-0003-2339-958X
Sirio CocozzaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0002-0300-5160
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Paola DazzanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8427-3617
Andrea de BartolomeisDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0002-3188-5652
Marta Di FortiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3218-6925
Alexandre DumaisDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.ORCID http://orcid.org/0000-0002-4480-0064
Jesse T EdmondTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Dresden, Germany.
Ulrika EvermannDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-3250-7821
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7738-5429
Foivos GeorgiadisDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-8784-9653
David C GlahnDepartment of Psychiatry, Harvard Medical School, Harvard, MA, USA.ORCID http://orcid.org/0000-0002-4749-6977
Janik GoltermannInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-3087-1002
Melissa J GreenNeuroscience Research Australia, Randwick, Australia.ORCID http://orcid.org/0000-0002-9361-4874
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-8718-0128
Amalia Guerrero-PedrazaHospital Benito Menni CASM, Barcelona, Spain.
Minji HaDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
Elliot L HongDepartment of Psychiatry and Behavioral Science, UTHealth Houston, Houston, TX, USA.
Hilleke Hulshoff PolDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2038-5281
Felice IasevoliDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0002-7051-5013
Stefan KaiserDepartment of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
Vasily KaledaDepartment of Youth Psychiatry, Mental Health Research Center, Moscow, Russia.
Andriana KarukFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2876-7268
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.ORCID http://orcid.org/0000-0001-8668-0817
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
Matthias KirschnerDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-9486-1439
Peter KochunovDepartment of Psychiatry and Behavioral Science, UTHealth Houston, Houston, TX, USA.
Jun Soo KwonDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.ORCID http://orcid.org/0000-0002-1060-1462
Irina LebedevaLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Rebekka LencerInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-4032-7297
Tiago R MarquesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0602-7661
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2177-7161
Robin MurrayInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0829-0519
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0749-7473
Dana NguyenDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Godfrey PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford, IN, USA.ORCID http://orcid.org/0000-0002-7525-5185
Fabrizio PirasLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-3566-5494
Edith Pomarol-ClotetFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0001-5425-1890
Stéphane PotvinDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
Adrian PredaDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Yann QuidéNeuroscience Research Australia, Randwick, Australia.ORCID http://orcid.org/0000-0002-8569-7139
Amanda RodrigueDepartment of Psychiatry, Harvard Medical School, Harvard, MA, USA.ORCID http://orcid.org/0000-0002-3403-6349
Kelly Rootes-MurdyTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Raymond SalvadorFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
Kang SimDepartment of Research, Institute of Mental Health, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3209-9626
Antonin SkochNational Institute of Mental Health, Klecany, Czech Republic.ORCID http://orcid.org/0000-0002-1739-3256
Gianfranco SpallettaLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-7432-4249
Filip SpanielNational Institute of Mental Health, Klecany, Czech Republic.ORCID http://orcid.org/0000-0003-3479-696X
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0003-4912-8307
Andràs TikàszDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
David TomecekNational Institute of Mental Health, Klecany, Czech Republic.ORCID http://orcid.org/0000-0001-7038-0529
Alexander TomyshevLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Mario TranfaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0002-4451-4746
Uyanga TsogtDepartment of Psychiatry, Jeonbuk National University, Jeonju, South Korea.
Jessica A TurnerPsychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA.ORCID http://orcid.org/0000-0003-0076-8434
Theo G M van ErpDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Neeltje E M van HarenDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-3090-7653
Jim van OsDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Daniela VecchioLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-8428-7376
Lei WangPsychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA.
Adrian WroblewskiDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0371-7686
Thomas Nickl-JockschatDepartment of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.ORCID http://orcid.org/0000-0003-2616-6503
Funding
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kNIBIB NIH HHS R01 EB015611NIH HHS S10 OD023696NIMH NIH HHS RF1 MH123163
Abstract
It is hypothesised that structural brain abnormalities in individuals with schizophrenia are associated with aggressive behaviour, but this has not been tested directly. We pooled magnetic resonance imaging and clinical data from 2095 patients and 2861 healthy control subjects across 20 sites of the ENIGMA-Schizophrenia Working Group. Using normative modelling, we quantified individual-level deviations from controls (z-scores) for global and regional grey matter volume and white matter microstructural integrity. Ordinal regression models were used to estimate the associations between these deviations and concurrent aggression (odds ratios [ORs] with 99% confidence intervals [CIs]). In mediation analyses, we examined the roles of positive symptoms - delusions, hallucinations and disorganised thinking - impulsivity and illness insight. Aggression was significantly associated with reductions in total cortical volume (OR [99% CI] = 0.88 [0.78, 0.98], p = 0.003), global white matter integrity (OR [99% CI] = 0.72 [0.59, 0.88], p = 3.50 × 10
Indexed as
AggressionBrainSchizophreniaAdultCase-Control StudiesFemaleGray MatterHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMiddle AgedSchizophrenic PsychologyWhite Matter
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