Evidence map›Paper›PMID 41339644›Full record

ArticleScientific reports2025

The accumulation of extracellular K

Valentina Carpentieri, Christophe Bernard, Michele Migliore

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Valentina CarpentieriInstitute of Biophysics, Consiglio Nazionale Delle Ricerche, Palermo, Italy.
Christophe BernardAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Michele MiglioreInstitute of Biophysics, Consiglio Nazionale Delle Ricerche, Palermo, Italy. michele.migliore@cnr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal electrical activity in the brain. Experimentally, it is studied using animal models relying on artificial external induction protocols. However, this does not accurately reflect what may occur in vivo, and the processes underlying how and under which condition an otherwise normal neuronal activity can lead to a seizure are poorly understood. To better understand these processes in a hippocampal CA1 pyramidal neuron, we have implemented and validated a realistic computational model to investigate how and to what extent a local dendritic accumulation of extracellular K

Indexed as

CA1 Region, HippocampalEpilepsyPotassiumPyramidal CellsAnimalsAstrocytesComputer SimulationDisease Models, AnimalModels, NeurologicalPotassiumCA1Computational modelEpilepsyExtracellular potassium accumulationHippocampus

Identifiers

PMID41339644
PMCPMC12756219

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.