Evidence map›Paper›PMID 41339625›Full record

ArticleNPJ science of food2025

Initial allergenicity assessment of Ulva sp. seaweed flour.

Odeya Kedar, Alexander Golberg, Uri Obolski, Efraim Steinbruch, Alexander Chemodanov, Álvaro Israel, Yoav D Livney, Idit Lachover-Roth, Yossi Rosman, Ronit Confino-Cohen

Registry-linked trialAbstract read
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06452381 (Towards Sustainable Food Systems), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06452381 unknown statusnot on this map

Towards Sustainable Food Systems: Allergenicity Assessment of Green Marine Macroalga Ulva sp.

Typeobservational_patient_registrySponsorMeir Medical CenterRan2022 to 2025Enrolled120ConditionsFood Allergy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Odeya KedarSchool of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. odeyakedar@mail.tau.ac.il.
Alexander GolbergSchool of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
Uri ObolskiDepartment of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Efraim SteinbruchSchool of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
Alexander ChemodanovSchool of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
Álvaro IsraelIsrael Oceanographic and Limnological Research Ltd. (PBC), Tel Shikmona, Haifa, Israel.
Yoav D LivneyFaculty of Biotechnology and Food Engineering, The Technion - Israel Institute of Technology, Haifa, Israel.
Idit Lachover-RothAllergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel.
Yossi RosmanAllergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel.
Ronit Confino-CohenAllergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel. ronitco@clalit.org.il.

Funding

Ministry of Health, State of Israel #3-16052
6 · The paper itself

Abstract

Ulva sp. is a green marine macroalga and a promising yet underexplored sustainable food source, with limited research on its allergenicity. This study evaluated the allergenic potential of Ulva sp. demineralized biomass flour (Ulva-DBF) using a weight-of-evidence approach inspired by regulatory assessments for novel foods, combining literature review, proteomic analysis, and a pilot clinical trial. Literature revealed no documented Ulva allergenicity. Proteomic analysis identified a few putative allergens, with estimated allergenic potential below 0.02%. In a pilot clinical trial (registered at ClinicalTrials.gov, Identifier: NCT06452381; First Posted Date: June 11, 2024), 31 participants consumed Ulva-DBF. No allergic reactions occurred, although 16.6% reported gastrointestinal discomfort. These findings represent a preliminary evaluation phase before widespread exposure. Nevertheless, large-scale consumption remains the most effective way to assess public health risks associated with any food. As we seek innovative and sustainable food solutions, post-marketing monitoring is vital to ensure their safety.

Identifiers

PMID41339625
PMCPMC12764789

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.