Evidence map›Paper›PMID 41339621›Full record

ArticleNPJ microgravity2025

The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis.

Ying Xu, Yunan Ding, Weiwei Pei, Miaomiao Zhang, Xiaofei Wang, Qi Zeng, Tom K Hei, Wentao Hu, Guangming Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying XuState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Yunan DingState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Weiwei PeiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Miaomiao ZhangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Xiaofei WangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Qi ZengDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Tom K HeiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China. tkh1@cumc.columbia.edu.
Wentao HuState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China. wthu@suda.edu.cn.
Guangming ZhouState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China. gmzhou@suda.edu.cn.

Funding

National Natural Science Foundation of China 32071243, 12475350, 82192882National Natural Science Foundation of China 82192883
6 · The paper itself

Abstract

Microgravity can exacerbate radiation-induced DNA damage response, suggesting that microgravity may increase the risk of tumor initiation and development. However, the specific mechanism is still unclear. This study used X-rays, protons, and carbon ions to simulate space radiation, and three-dimensional clinostats or hind limb unloading to simulate microgravity. It was found that simulated space radiation and/or microgravity promoted malignant transformation and tumor development of lung epithelial cells BEAS-2B, and the two factors showed a synergistic effect. The mechanism involves simulated space radiation and/or microgravity leads to changes in intracellular calcium ion concentration, affecting cellular signaling pathways, inducing the interaction between CAMK2G and ARRB1, and promoting ARRB1 nuclear translocation. ARRB1 nuclear translocation enhances CA9 transcriptional activity following simulated space radiation and/or microgravity exposure. In short, changes in intracellular calcium concentration play a crucial role in ARRB1 nuclear translocation and subsequent malignant transformation.

Identifiers

PMID41339621
PMCPMC12775490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.