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ArticleClinical oral investigations2025

Dynamic biomechanical simulation of long-term tooth movement in clear aligners extraction treatment through iterative macro-micro cycles.

Xinwei Lyu, Luxian Chen, Huilin Li, Tian Yang, Siyuan Ma, Liping Liu, Cheng Hu, Wei Kuang, Jiali Tan

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Xinwei Lyu *Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Luxian Chen *Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Huilin LiHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Tian YangHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Siyuan MaHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Liping LiuHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Cheng HuHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Wei KuangDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, Guangdong, China. 7409649@qq.com.
Jiali TanHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China. tanjiali@mail.sysu.edu.cn.

Funding

Guangzhou Key Research and Development Program 2024B03J0497National Natural Science Foundation of China 82471013Open Funding of Guangdong Provincial Key Laboratory of Stomatology KF2022120102the Postdoctoral Fellowship Program of CPSF GZC20233252
6 · The paper itself

Abstract

objectivesThis study aims to propose an iterative finite element method to simulate and analyze the long-term biomechanical responses during space closure in clear aligner therapy (CAT) extraction treatment. MATERIALS AND

methodsA patient-specific FE model was reconstructed from cone beam computed tomography and intraoral scanning. An innovative algorithm has been developed to automate the generation of CA model sequences for subsequent force loading and to enable dynamic simulation through real-time updates of teeth and periodontal ligament (PDL) positions. Each aligner was simulated in 10 iterations ("micro-cycle"), and the full treatment consisted of 30 aligners with 0.25 mm/step ("macro-cycle").

resultsThe algorithm achieved complete space closure. In the macro-cycle, torque control gradually escalated as the extraction gap narrowed, leading to a reversal in the direction of root movement of anterior teeth in the 16th aligner. In the micro-cycle, the initial displacement of the anterior teeth accounts for 36% to 65% of the cumulative displacement, with the contact stress initially distributed evenly across the labial surface of the dental crown, gradually concentrating on the labial cervix and lingual incisal sites.

conclusionsChanges in contact stress led to altered tooth movement, initially tipping and later torque movements during space closure. Cumulative displacements, rather than initial responses, should represent tooth movement tendency. CLINICAL RELEVANCE: The proposed methods can be integrated into existing clinical software platforms and advance precision treatment planning through biomechanical simulation. Based on the biomechanical results, personalized staging strategies and overcorrection can be made to alleviate side effects.

Indexed as

Orthodontic Space ClosureTooth ExtractionTooth Movement TechniquesAlgorithmsBiomechanical PhenomenaComputer SimulationCone-Beam Computed TomographyDental Stress AnalysisFinite Element AnalysisHumansPeriodontal LigamentBiomechanicsClear aligner therapyDynamic simulationFinite element methodsLong-term tooth movement

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.