GSH and CES2 dual-responsive biosensor for dual-signal electron spin resonance (ESR) sensing and free radical-enhanced triple-mode therapy of hepatocellular carcinoma.

Meijun Lu, Chen Zhao, Mo Ma, Hui Shi, Mingming Lu, Yuan Tian, Daqian Song, Ziwei Zhang

Abstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meijun LuCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Chen ZhaoCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Mo MaCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Hui ShiCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Mingming LuCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Yuan TianCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Daqian SongCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.

Ziwei ZhangCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China. zzw@jlu.edu.cn.

Funding

Jilin Provincial Department of Ecology and Environment 2024-17

6 · The paper itself

Abstract

The abnormally high expression of glutathione (GSH) in hepatocellular carcinoma (HCC) cells significantly contributes to chemotherapy resistance by neutralizing reactive oxygen species (ROS). To address this problem, we developed a nanocomposite probe (micelle@PDA@MnO

Indexed as

Biosensing TechniquesCarcinoma, HepatocellularGlutathioneLiver NeoplasmsAnimalsElectron Spin Resonance SpectroscopyFree RadicalsHep G2 CellsHumansIndolesManganese CompoundsMiceMicellesNanocompositesOxidesPolymersFree RadicalsGlutathioneIndolesManganese CompoundsMicellesOxidespolydopaminePolymersESR spectroscopyFree radicalGSHHCC therapyHepatoma cell discriminationNanocomposite probe

Identifiers

PMID41339579

DOI10.1016/j.cclet.2024.110773

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.