Evidence map›Paper›PMID 41339559›Full record

ArticleNature2026

TSC tunes progenitor balance and upper-layer neuron generation in neocortex.

Cristine R Casingal, Naoki Nakagawa, Keiko Yabuno-Nakagawa, Cailyn Meyer, Siling Liu, Vasiliki Gkini, Su-Ji Cho, Mario Skarica, Dan Liang, Jeremy M Simon and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Cristine R CasingalUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Naoki NakagawaUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Keiko Yabuno-NakagawaUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Cailyn MeyerUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Siling LiuUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Vasiliki GkiniNeuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Su-Ji ChoUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Mario SkaricaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Dan LiangUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Jeremy M SimonDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Nana MatobaUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Ahana MallickUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rubal SinglaUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Jieun ParkUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Chu-Wei HuangUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Hailey WilsonUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Janice LeeUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
H Troy GhashghaeiDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Garret D StuberDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Oskari HeikinheimoDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Takashi NambaNeuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Jason L SteinUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
E S AntonUNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA. anton@med.unc.edu.ORCID 0000-0002-8817-6750

Funding

DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITYR35NS116859 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVA S ANTON · 2020 to 2026
$4.1M
Primary Cilia: A Novel Signaling Gateway To Neural Circuit ModulationRF1MH132710 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, LICHTMAN, JEFF W · 2025 to 2025
$2.2M
NIMH NIH HHS RF1 MH132710NINDS NIH HHS R35 NS116859
6 · The paper itself

Abstract

The appropriate generation of upper-layer neurons is necessary to create the circuits that underlie complex brain functions. Radial progenitors divide asymmetrically to generate neurogenic intermediate progenitors (IPs; also known as intermediate precursors), and the symmetric proliferation of IPs rapidly expands the cortical neuronal population. The dynamic maintenance of balanced diversity of cortical progenitors and the resultant generation, placement and connectivity of appropriate numbers of different classes of neurons serve to guide the formation of a properly wired cerebral cortex

Indexed as

NeocortexNeural Stem CellsNeurogenesisNeuronsTumor Suppressor ProteinsAnimalsEnhancer Elements, GeneticFemaleHumansMaleMiceTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTSC1 protein, humanTsc1 protein, mouseTSC2 protein, humanTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Suppressor Proteins

Identifiers

PMID41339559
PMCPMC13052830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.