Evidence map›Paper›PMID 41339340›Full record

ArticleNPJ science of food2025

Untargeted metabolomics approaches challenge the nutri-score FOPNL system in soluble cocoa products.

Marta Palma-Morales, Oscar Daniel Rangel-Huerta, Rafael Urrialde, Celia Rodríguez-Pérez

Abstract read
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Marta Palma-MoralesDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Cartuja Campus, Granada, Spain.
Oscar Daniel Rangel-HuertaSection of Chemistry and Toxinology, Norwegian Veterinary Institute, P.O. Box 64, N-1431, Ås, Norway. od.rangel7@gmail.com.
Rafael UrrialdeDepartment of Genetics, Physiology and Microbiology, Universidad Complutense de Madrid, Madrid, Spain.
Celia Rodríguez-PérezDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Cartuja Campus, Granada, Spain.

Funding

Government of Spain FPU22/02472Junta de Andalucía-Consejería de Universidad, Investigación e Innovación P21_00777
6 · The paper itself

Abstract

Front-of-pack nutrition labels (FOPNL) like the Nutri-Score aim to guide healthier food choices, but their focus on limited nutritional parameters may overlook key health-promoting compounds. This study analyzed 54 commercial soluble cocoa powders from the Spanish market-covering 19 brands and Nutri-Score categories A to D-using untargeted metabolomics (HPLC-ESI-TOF-MS) and univariate and multivariate statistical analysis. PCA and PLS2 analyses showed no clear clustering by Nutri-Score categories, while ANOVA and post-hoc tests revealed limited metabolic differences, highlighting a mismatch between Nutri-Score classification and the actual chemical diversity of soluble cocoa products. Nutri-Score ratings primarily reflect macronutrient balance but fail to account for health-promoting metabolites. In several cases, products richer in bioactive compounds were penalized with lower Nutri-Scores, underscoring a limitation of this system when applied to complex food matrices. These findings highlight the need for more comprehensive labeling approaches that integrate metabolomic insights.

Identifiers

PMID41339340
PMCPMC12770576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.