Evidence map›Paper›PMID 41339294›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2026

An Early-Stage Nuclear Protein in Testis Carcinoma of the Lung in an Older Woman.

Guangyao Shan, Dejun Zeng, Wen Huang, Guangyu Yao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guangyao ShanDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0002-2993-5817
Dejun ZengDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wen HuangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Guangyu YaoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy often diagnosed late due to non-specific symptoms and low awareness. A 69-year-old woman presented with haemoptysis and a positron emission tomography-avid lung nodule (cT1N0M0). An initial bronchoscopic biopsy suggested small cell carcinoma with negative NUT staining. Following a lobectomy, immunohistochemical analysis showed strong nuclear NUT positivity, and fluorescence in situ hybridization confirmed NUT rearrangement. This case was atypical due to the patient's age, early stage, and initial misdiagnosis from a limited biopsy. The non-specific presentation of an NUT carcinoma requires a high degree of suspicion, and small biopsies risk a misdiagnosis.

Indexed as

Biomarkers, TumorLung NeoplasmsNeoplasm ProteinsNuclear ProteinsOncogene ProteinsAgedBiopsyBronchoscopyFemaleGene RearrangementHumansImmunohistochemistryIn Situ Hybridization, FluorescencePneumonectomyBiomarkers, TumorNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanOncogene Proteinslung cancerNUT geneNUT midline carcinoma

Identifiers

PMID41339294
PMCPMC12774462

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.