ArticleACS chemical neuroscience2025
Functionalization of 1,3-Diisopropylbenzene to Probe the Antagonism of Propofol Anesthesia.
Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
General anesthetics like propofol are widely used, but their molecular mechanisms remain poorly understood, limiting the rational design of novel anesthetics or antagonists to enhance safety. We evaluated nine propofol derivatives for their ability to immobilize, or modulate propofol-induced immobilization, in larval zebrafish, using spontaneous and elicited movement as distinct endpoints. We hypothesized that compounds unable to act as hydrogen-bond donors would antagonize immobilization─evidenced by rightward EC
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