Evidence map›Paper›PMID 41338393›Full record

ArticleVirus research2026

Foot-and-mouth disease virus 3D polymerase antagonizes the interferon signaling pathway by blocking STAT2 nuclear translocation.

Kangli Li, Boning Zhu, Shuo Wang, Xiangle Zhang, Xiaodan Wen, Weijun Cao, Guoliang Zhu, Haixue Zheng, Fan Yang, Zixiang Zhu

Erratum issuedAbstract read
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In one paragraph

Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kangli LiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China.
Boning ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China.
Shuo WangSchool of Pharmacy, Lanzhou University, 199 West Donggang Rd, Lanzhou 730000, China.
Xiangle ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
Xiaodan WenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China.
Weijun CaoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China.
Guoliang ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Haixue ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; WOAH/National reference laboratory for foot-and-mouth disease, Lanzhou 730046, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
Fan YangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Electronic address: yangfan02@caas.cn.
Zixiang ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Electronic address: zhuzixiang@caas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) is the etiological agent of foot-and-mouth disease (FMD), which is highly contagious and extremely destructive in cloven-hoofed animals. Previous studies have shown that FMDV strongly suppress the innate immune response, and the research mainly focused on FMDV 3C and L proteinase. However, the role of FMDV 3D polymerase, an RNA-dependent RNA polymerase (RdRp), in inhibiting the IFN signaling pathway remains unclear. In this study, for the first time, we demonstrate that the highly conserved 3D polymerase of FMDV inhibits the activation of the JAK-STAT signaling pathway by targeting STAT2. Mechanistically, FMDV 3D significantly inhibits the activity of the interferon-stimulated response element promoter and downregulates the transcription of interferon-stimulated genes. Further research revealed that 3D interacts with STAT2, hinders its phosphorylation, and inhibits its nuclear translocation, thereby blocking the activation of the JAK-STAT signaling pathway. Collectively, these findings elucidate a novel mechanism by which FMDV 3D polymerase, acting as an inhibitor, targets STAT2 to suppress IFN signaling and antagonize the host antiviral immune response. This will provide insights for the development of future anti-FMDV strategies.

Indexed as

Foot-and-Mouth Disease VirusInterferonsRNA-Dependent RNA PolymeraseSignal TransductionSTAT2 Transcription FactorViral Nonstructural ProteinsActive Transport, Cell NucleusAnimalsCell LineCell NucleusFoot-and-Mouth DiseaseHost-Pathogen InteractionsHumansImmunity, InnatePhosphorylationInterferonsRNA-Dependent RNA PolymeraseSTAT2 Transcription FactorViral Nonstructural Proteins3D proteinFMDVInnate immune responseNuclear translocationSTAT2

Identifiers

PMID41338393
PMCPMC12741290

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.