Evidence map›Paper›PMID 41338342›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Development of a light-induced gas phase nitric oxide generator and its use in killing biofilm bacteria in vitro and ex vivo.

Gergely Lautner, Partha S Sheet, Mohsen Tabasi, Haleh Ganijan, Hannah J Naldrett, Blake Stringer, Jeremy Schwartz, Joshua Doverspike, Denis Hadjiliadis, Jianfeng Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gergely LautnerDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States of America. Electronic address: glautner@umich.edu.
Partha S SheetDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States of America.
Mohsen TabasiCenter for inflammation and Lung Research, Temple University, Philadelphia, PA 19140, United States of America.
Haleh GanijanCenter for inflammation and Lung Research, Temple University, Philadelphia, PA 19140, United States of America.
Hannah J NaldrettDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States of America.
Blake StringerDepartment of Chemistry, LSA, University of Michigan, Ann Arbor, MI 48109, United States of America.
Jeremy SchwartzDepartment of Chemistry, LSA, University of Michigan, Ann Arbor, MI 48109, United States of America.
Joshua DoverspikeDepartment of Chemistry, LSA, University of Michigan, Ann Arbor, MI 48109, United States of America.
Denis HadjiliadisPulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, United States of America.
Jianfeng WuDepartment of Environmental Health, University of Michigan School of Public Health, Ann Arbor, MI 48109, United States of America.
Chuanwu C XiDepartment of Environmental Health, University of Michigan School of Public Health, Ann Arbor, MI 48109, United States of America.
Mark E MeyerhoffDepartment of Chemistry, LSA, University of Michigan, Ann Arbor, MI 48109, United States of America.
Umadevi SajjanCenter for inflammation and Lung Research, Temple University, Philadelphia, PA 19140, United States of America; Department of Microbiology, Immunology and Inflammation, Temple University, Philadelphia, PA 19140, United States of America; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, United States of America. Electronic address: uma.sajjan@temple.edu.
Steven P SchwendemanDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States of America; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States of America. Electronic address: schwende@umich.edu.

Funding

Controlled Photochemical Release of Nitric Oxide for Biomedical ApplicationsR01EB028775 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, STEVEN P. · 2020 to 2023
$1.8M
NIBIB NIH HHS R01 EB028775
6 · The paper itself

Abstract

In order to overcome the high costs and logistical issues associated with nitric oxide (NO) storage tanks, a portable tankless prototype device has been developed for precise controlled release of inhaled nitric oxide (iNO) gas from a solid NO donor, S-nitroso-N-acetyl penicillamine (SNAP) stored within "coffee pod" style replaceable cartridges. The device utilizes LED light to trigger the release of NO from SNAP, and the concentration of the delivered NO gas is continuously monitored with amperometric sensors and regulated by a feedback control system via modulating the light intensity. The system enables facile adjustment of NO concentrations, allowing for the reliable delivery of low-dose NO (up to 10 ppm, as demonstrated here) across clinically relevant air flow rates, with the prototype specifically designed for air flow up to 4 L/min. Importantly, NO generation is achieved without the need for nitrogen (N₂) as a carrier gas, enabling safe and simple operation using ambient air even in home settings. To ensure the safety of this device, the key factors affecting the formation of the major undesired impurity, nitrogen dioxide (NO

Indexed as

BiofilmsNitric OxideNitric Oxide DonorsS-Nitroso-N-AcetylpenicillamineAdministration, InhalationGasesHumansLightPseudomonas aeruginosaGasesNitric OxideNitric Oxide DonorsS-Nitroso-N-AcetylpenicillamineBiofilm dispersionInhalationNitric oxidePhotolysisPrototype deviceRSNO

Identifiers

PMID41338342
PMCPMC12951814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.