Evidence map›Paper›PMID 41338245›Full record

ArticleBone & joint open2025

The Clinical Frailty Scale is a valid and independent predictor of one-year survival in patients sustaining a hip fracture : scottish Hip Fracture Audit data from 8,092 patients.

Matthew J Kennedy, Rose S Penfold, Lorraine Donaldson, Andrew J Hall, Martin J Davison, Alasdair M J MacLullich, Phil Walmsley, Nick D Clement, Jon V Clarke

Registry-linked trialAbstract read
In one paragraph

Article in Bone & joint open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07481188 (Incremental Prognostic Value of Frailty Beyond the Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07481188 recruitingnot on this mapstarted 2026, after this paper: background citation

Incremental Prognostic Value of Frailty Beyond the Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery: A Prospective Cohort Study

TypeobservationalSponsorTrakya UniversityRan2026 to 2027Enrolled200ConditionsHip Fracture, Proximal Femur Fracture, FrailtyArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew J KennedyScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Rose S PenfoldScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Lorraine DonaldsonScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Andrew J HallScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Martin J DavisonScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Alasdair M J MacLullichScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Phil WalmsleySchool of Medicine, University of St Andrews, St Andrews, UK.
Nick D ClementScottish Hip Fracture Audit, Public Health Scotland, Edinburgh, UK.
Jon V ClarkeGolden Jubilee University National Hospital, Clydebank, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Hip fracture patients have a significant mortality risk. Risk stratification tools are important in guiding management and family discussions. Aims were to assess the associations and validity of the Clinical Frailty Scale (CFS) in predicting mortality and return to original residence within 30 days using national hip fracture registry data. Methods: Routinely collected clinical registry data for all patients presenting with a hip fracture in Scotland aged 50 years and over between February 2022 and December 2023 with a completed CFS score were analyzed. The association of frailty with mortality and return to original residence was assessed using multivariable Cox regression and logistic regression analysis, respectively, adjusting for confounders to present adjusted hazard (aHRs) and odds ratios (aORs). Results: Of 15,546 patients, 8,573 had completed the CFS. Exclusion for missingness gave a final sample of 8,092. Most (71.4%) were female with a median American Society of Anesthesiologists (ASA) grade of 3 (IQR 3 to 3) and CFS of 5 (IQR 4 to 7). Vulnerable and frail patients (CFS ≥ 4) were older, more likely to be admitted from a higher care setting, and had increased mortality risk on the same admission. Higher CFS scores were associated with increased mortality risk: mildly frail (CFS 4 to 5), aHR 1.67 (95% CI 1.53 to 1.87); and frail (CFS 6 to 8), aHR 3.01 (95% CI 2.59 to 3.50). CFS and ASA grade showed similar performance in predicting one-year mortality (CFS area under curve (AUC) 0.72, 95% CI 0.71 to 0.73; ASA AUC 0.66, 95% CI 0.65 to 0.67) and return to residence (CFS AUC 0.63, 95% CI 0.62 to 0.65; ASA AUC 0.61, 95% CI 0.60 to 0.62). Conclusion: The CFS is a pragmatic and validated tool for assessing frailty, which has a strong association with mortality risk in patients with hip fractures. Its predictive accuracy supports its integration into national hip fracture registries. While its utility in predicting return to pre-injury residence is moderate, it remains a valuable component of comprehensive patient assessment.

Identifiers

PMID41338245
PMCPMC12674844

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.