Evidence map›Paper›PMID 41338196›Full record

ArticleCurrent biology : CB2025

Non-uniform signal pooling across the foveola.

Krishnamachari S Prahalad, Ashley M Clark, Benjamin Moon, Austin Roorda, Pavan Tiruveedhula, Wolf Harmening, Aleksandr Gutnikov, Samantha K Jenks, Sanjana Kapisthalam, Michele Rucci and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Krishnamachari S PrahaladDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA. Electronic address: pkrishn5@ur.rochester.edu.
Ashley M ClarkDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA.
Benjamin MoonCenter for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA; Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
Austin RoordaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, 581 Minor Hall, Berkeley, CA 94720, USA.
Pavan TiruveedhulaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, 581 Minor Hall, Berkeley, CA 94720, USA.
Wolf HarmeningDepartment of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Aleksandr GutnikovDepartment of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Samantha K JenksDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA.
Sanjana KapisthalamDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA.
Michele RucciDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA; Department of Neuroscience, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Jannick P RollandCenter for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA; Institute of Optics, University of Rochester, Rochester, NY 14627, USA; Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA.
Martina PolettiDepartment of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA; Center for Visual Science, University of Rochester, 361 Meliora Hall, Rochester, NY 14627, USA; Department of Neuroscience, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Function of Fixational Instability During Natural ViewingR01EY018363 · NEI · UNIVERSITY OF ROCHESTER · PI RUCCI, MICHELE · 2007 to 2025
$7.8M
Vision, Attention and Eye Movements at the Scale of the FoveolaR01EY029788 · NEI · UNIVERSITY OF ROCHESTER · PI Martina Poletti · 2019 to 2026
$3.4M
NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY018363NEI NIH HHS R01 EY023591NEI NIH HHS R01 EY029788
6 · The paper itself

Abstract

Object recognition is impacted by visual crowding. This phenomenon, attributed to cortical pooling, is generally studied in the periphery. Crowding mechanisms in the foveola-the 1° retinal region with highest resolution-remain unclear due to difficulties in controlling for optical factors and incessant fixational eye motion. Using high-resolution retinal imaging and retinal-contingent stimulus rendering to overcome these limitations, we demonstrated that the critical spacing at the preferred retinal locus approximates a single cone's diameter. However, just 0.25° away, mislocalization errors start to occur and the extent of crowding exceeds cone spacing. These results reveal that cortical pooling mechanisms may play a greater role with increasing foveolar eccentricity and point to a possible cortical magnification gradient effect within the central fovea.

Indexed as

Fovea CentralisHumansPhotic StimulationRetinal Cone Photoreceptor Cellscortical magnificationfixation eye movementsfoveolar visionhigh-resolution retinal imagingvisual crowding

Identifiers

PMID41338196
PMCPMC13244582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.