Evidence map›Paper›PMID 41337752›Full record

ArticleACS chemical biology2025

Selectivity of the Time-Dependent

Mingqian Wang, YongLe He, Siobhan A Cohen, Amanda R Strohm, Gauri Shetye, Scott G Franzblau, Stephen G Walker, M R K Alley, Peter J Tonge

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingqian WangCenter for Advanced Study of Drug Action, and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
YongLe HeCenter for Advanced Study of Drug Action, and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0001-7274-535X
Siobhan A CohenCenter for Advanced Study of Drug Action, and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Amanda R StrohmCenter for Advanced Study of Drug Action, and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0009-0003-2334-9504
Gauri ShetyeInstitute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States.ORCID 0000-0001-6282-2833
Scott G FranzblauInstitute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States.ORCID 0000-0002-8698-0243
Stephen G WalkerDepartment of Oral Biology and Pathology, Stony Brook University, Stony Brook, New York 11794, United States.
M R K AlleyAN2 Therapeutics, Menlo Park, California 94027, United States.
Peter J TongeCenter for Advanced Study of Drug Action, and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0003-1606-3471

Funding

Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR35GM149297 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PETER J TONGE · 2023 to 2026
$1.6M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM148331 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Styliani-Anna (Stella) E Tsirka · 2024 to 2026
$695k
NIGMS NIH HHS R35 GM149297NIGMS NIH HHS T32 GM136572NIGMS NIH HHS T32 GM148331
6 · The paper itself

Abstract

Ganfeborole (GSK3036656) inhibits the

Indexed as

Antitubercular AgentsBoron CompoundsEnzyme InhibitorsLeucine-tRNA LigaseMycobacterium tuberculosisEscherichia coliMicrobial Sensitivity TestsAntitubercular AgentsBoron CompoundsEnzyme InhibitorsLeucine-tRNA Ligase

Identifiers

PMID41337752
PMCPMC12818446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.