Evidence map›Paper›PMID 41337584›Full record

ArticleScience advances2025

An ultrasmall theranostic nanozyme for abdominal aortic aneurysm management and therapeutic efficacy monitoring.

Wanling Liu, Yihong Zhang, Xiaomiao Cui, Qi Sun, Xiang Gu, Tong Li, Shicheng He, Zhexue Qin, Hui Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wanling LiuDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0009-0007-9481-2083
Yihong ZhangDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0000-0002-0238-2124
Xiaomiao CuiDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0000-0002-5594-9390
Qi SunDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0009-0004-3613-2774
Xiang GuDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.
Tong LiDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0000-0002-2341-3372
Shicheng HeJinfeng Laboratory, Chongqing 401329, P. R. China.
Zhexue QinDepartment of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, P. R. China.
Hui WeiDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0000-0003-0870-7142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective drug interventions, and its progression is difficult to predict, complicating early clinical management. Here, we present a reactive oxygen species-responsive theranostic nanozyme for AAA early intervention and efficacy monitoring, establishing a feedback loop between treatment and diagnostics. OZn, designed by encapsulating ultrasmall Prussian blue (SPBZn) within oxidation-sensitive dextran, targets aneurysm sites, where it responds to inflammatory microenvironments by releasing SPBZn. In vivo, SPBZn not only mitigated CaCl

Indexed as

Aortic Aneurysm, AbdominalFerrocyanidesTheranostic NanomedicineAnimalsDisease Models, AnimalHumansMaleRatsReactive Oxygen Speciesferric ferrocyanideFerrocyanidesReactive Oxygen Species

Identifiers

PMID41337584
PMCPMC12674130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.