ArticleProceedings of the National Academy of Sciences of the United States of America2025
Guiding esophagectomy with intraoperative NIR-II fluorescence video imaging and rapid computation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Preclinical shortwave infrared/near-infrared II (SWIR/NIR-II, 1,000 to 3,000 nm) fluorescence imaging has shown superior contrast, resolution, and penetration depth compared to traditional near-infrared I (NIR-I, 700 to 900 nm) imaging, owing to reduced light scattering and tissue autofluorescence. Here, we carried out clinical translation of NIR-II fluorescence imaging to guide esophagectomy through intraoperative video imaging and rapid analysis of blood perfusion in the gastric conduits (GC) of esophageal cancer patients, following intravenous administration of indocyanine green (ICG). Within <1 min, NIR-II video imaging clearly visualized the spatial and temporal blood flow features, and importantly, intraoperative principal component analysis (PCA) of the video revealed distinct perfusion patterns in GC. This led to rapid, subjective decision-making for targeted resection of poorly perfused tissue and informed reconstruction of the GC to reduce the risk of life-threatening anastomotic leakage. This approach enhances surgical precision and improves outcomes by providing operator-independent intraoperative guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.