Evidence map›Paper›PMID 41337483›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

TGFBR2 coordinates the endometrial response to estrogen, regulating endometrial hyperplasia and fertility.

Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sydney E ParksDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-4815-9972
Suni TangDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Anna Catherine UnserDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0009-0001-4678-1469
Ananya L BhonsleyDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Eunbi M ChungDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0009-0000-0063-2815
Peixin JiangDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Audrey SavolainenFaculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90220, Finland.ORCID 0000-0002-6801-8886
Vanessa J JosephDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Dominique I CopeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Ramya P MasandDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1529-5679
Renata Prunskaite-HyyryläinenFaculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90220, Finland.ORCID 0000-0001-5453-2983
Diana MonsivaisDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-5660-6392

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Discovery and development of potent inhibitors of Jun N-terminal kinase for non-hormonal treatment of endometriosis and associated painR01HD099341 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MONSIVAIS, DIANA · 2021 to 2025
$2.8M
Targeting the endometrial stem cell niche inendometriosisR01HD105800 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Diana Monsivais · 2022 to 2026
$2.5M
Comprehensive Mechanisms in Reproductive SciencesT32HD098068 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI STEPHANIE A. PANGAS · 2020 to 2026
$2.4M
ACQUISITION OF THE YOKOGAWA CV8000 HIGH THROUGHPUT SPINNING DISK MICROSCOPE AND ROBOTICSS10OD030414 · OD · BAYLOR COLLEGE OF MEDICINE · PI MANCINI, MICHAEL A. · 2022 to 2022
$1.4M
Burroughs Wellcome Fund (BWF) NGP10125HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01-HD099341HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01-HD105800HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32-HD098068-05S1HHS | NIH | National Cancer Institute (NCI) NCI-CA125123HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK56338HHS | NIH | NIH Office of the Director (OD) S10OD030414NCI NIH HHS P30 CA125123NICHD NIH HHS R01 HD099341NICHD NIH HHS R01 HD105800NICHD NIH HHS T32 HD098068NIDDK NIH HHS P30 DK056338NIH HHS S10 OD030414Research Council of Finland (AKA) 336449
6 · The paper itself

Abstract

Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cancer. The TGFβ signaling pathway regulates key aspects of endometrial biology, although the direct effects of many individual receptors remain unstudied. In this study, we characterize the role of TGFβR2 within the endometrium using a progesterone receptor-cre conditional knock-out mouse model (

Indexed as

Endometrial HyperplasiaEndometriumEstrogensFertilityReceptor, Transforming Growth Factor-beta Type IIAnimalsFemaleInfertility, FemaleMiceMice, KnockoutPregnancyProgesteroneReceptors, ProgesteroneSignal TransductionEstrogensProgesteroneReceptors, ProgesteroneReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseendometrial hyperplasiaendometriumestrogen responseorganoidspregnancy

Identifiers

PMID41337483
PMCPMC12704753

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.