ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2025
A Multi-Scale, High-Fidelity Computational Model of the Mouse Triceps Surae Motor Pool.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study introduces a novel, multi-scale, high- fidelity, computational model of the motoneuron pool innervating the mouse triceps surae muscle group. Designed to represent synaptic, anatomical, cellular, extracellular, and system-level dynamics, the model captures the unique electrical properties of mouse motoneurons. The model was rigorously validated against experimental measurements-including eleven key intracellular electrical properties and extracellular ventral root recordings-using extensive statistical analyses. These evaluations demonstrate that the model's properties closely match in vivo observations, ensuring its accuracy and biological relevance. Consequently, this model serves as a versatile tool for investigating motoneuron behavior and motor unit dynamics in mice, offering valuable insights into neuromuscular function and potential applications in studying motoneurons in healthy and disease conditions.
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