ArticleJournal of neuro-oncology2025
Disruption of cognitive flexibility and planning skills after childhood brain tumor treatment: clinical issues and comprehensive assessment.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
purposeThis study evaluated cognitive flexibility and planning in pediatric brain tumor survivors (PBTS) using a combined approach of performance-based tests (CEF-B) and rating measures (BRIEF). It also examined the impact of demographic and medical factors on these executive function (EFs) domains.
methodA convenience sample of 26 PBTS (ages 7–16), undergoing routine clinical follow-up, was assessed, with results compared to normative data and analyzed for correlations and congruence between a new performance-based battery (CEF-B) and questionnaire-based measures (BRIEF). Sociodemographic and treatment variables were explored for associations with EFs outcomes.
resultsThe findings revealed significant deficits in flexibility (75%) and planning (56%) tests compared to normative data, with questionnaires corroborating elevated deficits. However, correlations between the CEF-B and BRIEF were low. Congruence analyses show that teachers’ ratings aligned more closely with performance-based measures than parental ratings. As expected, younger age at diagnosis and lower maternal education were associated with more flexibility deficits, but no significant factors were linked to planning ones.
conclusionThis study highlights the clinical value of the CEF-B in identifying EF deficits in PBTS and supports integrating both performance-based and questionnaire assessments for a more comprehensive evaluation. Future research should investigate how EFs impairments affect interpersonal relationships and social cognition in PBTS.
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