ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025
Dose threshold values for endovascular photodynamic therapy (PDT) in normal pig pancreas and human pancreatic cancer.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Robustness of interstitial photodynamic therapy treatment planning under power and positional uncertainties in light delivery.Scientific reports · 2026Article
- Article
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10 authors.
Funding
Abstract
backgroundPancreatic cancers often involve major blood vessels, making complete surgical removal difficult or impossible. We are developing endovascular photodynamic therapy (PDT) as a novel minimally invasive ablation method to clear tumours from these vessels, to enable potentially curative surgery. The goal is to determine the required endovascular irradiation times for effective treatment.
methodsThreshold doses for PDT were estimated using Monte Carlo simulations, based on clinical data from previous Phase I/II studies involving Photodynamic Therapy of pancreatic cancer using interstitial needle-based irradiation. These thresholds were then compared to our recent in vivo study, which used endovascular catheter-based irradiation in a normal pig pancreas. Using these dose thresholds, we estimated the PDT irradiation times needed to achieve necrotic tissue margins of 4-12 mm around blood vessels in pancreatic cancer patients, based on a fixed energy range and increasing doses of photosensitiser.
resultsThe threshold dose for Verteporfin-mediated PDT was determined to be 1.43-2.37 × 10
conclusionsThese findings suggest that PDT can potentially create a margin around major pancreatic blood vessels free of viable tumour tissue. The calculated dosimetry supports the feasibility of clinical application using the proposed Verteporfin dose and light delivery parameters, warranting further investigation in Clinical trials.
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