ArticleMolecular neurobiology2025
miR-495-3p Attenuates Neuronal Apoptosis Through The Activation of Wnt/MAPK Pathways in Ischemic Stroke.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The incidence of ischemic stroke, involving neuronal cell death and damaged blood vessels, is gradually increasing. In this study, we investigated the effects of a miR-495-3p-I on neuronal viability and recovery using both oxygen-glucose deprivation and recovery (OGD/R) and in transient middle cerebral artery occlusion (tMCAo) models of ischemic stroke. Cell viability increased with miR-495-3p-I treatment compared with the OGD/R group, and both early and late apoptosis decreased through by flow cytometry analysis. In the tMCAo model, tissues injected with miR-495-3p-I showed upregulation of canonical Wnt pathway genes (cyclin D1 and c-Myc) and neuronal marker (Tuj1), while non-canonical Wnt/MAPK pathway genes (caspase-3 and -7) were downregulated. Expression of the pro-apoptotic marker Bax was reduced, whereas the Bcl-2 family protein Mcl-1 increased. Behavioral tests revealed improved motor function compared to the sham group and treatment with miR-495-3p-I reduced brain infarct volume. This research explored the function of miR-495-3p-I in Wnt and MAPK pathways by using the miR-495-3p-I in a model of ischemic stroke, a neurological disease. Thus, we demonstrated that miR-495-3p-I reduced apoptosis and enhanced neuronal cell survival, suggesting it could be a potential therapeutic target.
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