ArticleAnalytical and bioanalytical chemistry2026
The influence of sample temperature on water cluster ion formation for ToF-SIMS studies of frozen hydrated samples.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In time-of-flight secondary ion mass spectrometry (ToF-SIMS), analysis of frozen biological specimens at cryogenic temperatures is often necessary to maintain the native 3D structure of the specimen. Frozen hydrated analysis results in interferences from sputtered water cluster peaks that extend over the full spectral mass range. In this study, we have investigated the influence of the analysis temperature from 98 to 183 K on the water cluster spectrum from a frozen hydrated cell-free model biofilm system which contained the antibiotic ciprofloxacin. Below 163 K, the spectrum was dominated by sequences of water cluster ions of the form (H
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