Evidence map›Paper›PMID 41335240›Full record

ReviewNeurogenetics2025

Research progress of platelet-rich plasma in promoting peripheral nerve repair.

Fengqing Wu, Zekai Huang, Huan Yang, Hongbin Huang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fengqing Wu *Department of Orthopedics, Yiwu Central Hospital, Yiwu, Zhejiang Province, 322000, China.
Zekai Huang *Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang Province, 310015, China.
Huan YangHangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, 310051, China. 0622766@zju.edu.cn.
Hongbin HuangDepartment of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. ywgk1118@126.com.

Funding

Zhejiang Provincial Natural Science Foundation LTGY24H090001
6 · The paper itself

Abstract

Peripheral nerve injury (PNI) represents a significant clinical challenge, affecting millions globally and often resulting in permanent disability. Despite advances in microsurgical techniques, functional recovery remains suboptimal due to slow regeneration and incomplete nerve repair. This review critically examines the emerging role of platelet-rich plasma (PRP) in peripheral nerve regeneration, synthesizing current evidence from both preclinical and clinical studies. Recent clinical trials have demonstrated significant improvements in functional outcomes, particularly in carpal tunnel syndrome and facial nerve injuries. The integration of PRP with novel approaches, including tissue engineering and stem cell therapy, shows promise in addressing current therapeutic limitations. However, standardization of preparation protocols and large-scale clinical validation remain critical challenges. This review provides comprehensive insights into the therapeutic potential of PRP in peripheral nerve repair and highlights future research directions.

Indexed as

Nerve RegenerationPeripheral Nerve InjuriesPeripheral NervesPlatelet-Rich PlasmaAnimalsHumansTissue EngineeringAxon regenerationPeripheral nerve injuryPeripheral nerve regenerationPlatelet-rich plasmaSchwann cellsTissue engineering

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.