Evidence map›Paper›PMID 41335011›Full record

ArticleThe Journal of comparative neurology2025

Ventilatory Complexity Persists in Phox2b Mutant Mice Lacking the Retrotrapezoid Nucleus/Parafacial Respiratory Group (RTN/pFRG) and in Humans With Congenital Central Hypoventilation Syndrome.

Christian Straus, Anja Ranohavimparany, Nelina Ramanantsoa, Lysandre Tremoureux, Maxime Patout, Marie-Noëlle Fiamma, Florence Cayetanot, Boris Matrot, Jorge Gallego, Laurence Bodineau and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian StrausSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.ORCID 0000-0003-1564-0046
Anja RanohavimparanySorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Nelina RamanantsoaUniversité Paris Cité, Inserm UMR 1141, NeuroDiderot, Paris, France.
Lysandre TremoureuxSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Maxime PatoutSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Marie-Noëlle FiammaSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Florence CayetanotSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Boris MatrotUniversité Paris Cité, Inserm UMR 1141, NeuroDiderot, Paris, France.ORCID 0000-0002-7845-9618
Jorge GallegoUniversité Paris Cité, Inserm UMR 1141, NeuroDiderot, Paris, France.
Laurence BodineauSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.ORCID 0000-0002-0085-9021
Thomas SimilowskiSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.ORCID 0000-0003-2868-9279

Funding

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le SommeilMinistère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
6 · The paper itself

Abstract

Breathing is inherently variable due to the nonlinear dynamics of its brainstem neural control. In amphibians, a gill and a lung oscillator interact to produce breathing but the lung oscillator is necessary and sufficient to produce a mathematically complex behavior. In mammals, where the preBötzinger complex (preBötC) is considered homologous to the amphibian lung oscillator and the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) homologous to the amphibian gill oscillator, the origin of ventilatory complexity is not known. We address this question by characterizing ventilation variability in Phox2b mutant mice lacking the RTN/pFRG and human patients with Phox2b mutation-confirmed congenital central hypoventilation syndrome (CCHS). Ventilatory recordings were obtained from Phox2b

Indexed as

Homeodomain ProteinsHypoventilationRespirationRespiratory CenterSleep Apnea, CentralTranscription FactorsAnimalsFemaleHumansMaleMiceMice, TransgenicMutationHomeodomain ProteinsNBPhox proteinPhox2b protein, mouseTranscription Factorscentral respiratory pattern generatorscongenital central alveolar hypoventilationcontrol of breathingmathematical complexityPhox2b mutationsvariability

Identifiers

PMID41335011
PMCPMC12673958

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.