Trial reportPlastic and reconstructive surgery2026
Progression of Dupuytren Contracture: A Randomized Controlled Trial Comparing Surgery, Needle Fasciotomy, and Collagenase Injection.
Trial report in Plastic and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDupuytren contracture can be treated by surgery, needle fasciotomy, or collagenase injection, but how these treatments affect disease progression in both treated and untreated fingers is poorly understood. This study aimed to compare the progression of Dupuytren contracture across these 3 treatments over a 2-year follow-up and identify patients at highest risk for progression and retreatment.
methodsThis finger-level analysis used data from DETECT (Dupuytren Treatment Effectiveness Trial) and included 302 participants with 423 initially treated fingers. Progression was defined as an increase in contracture angle between 3 months and 2 years after treatment. Analyses included treated, adjacent untreated, and all untreated fingers. The authors used linear regression models to identify risk factors for progression and retreatment.
resultsOf the 302 participants, 279 (92%) completed 3-month contracture measurements and 274 (91%) completed 2-year contracture measurements. In treated fingers, surgery resulted in less progression than needle fasciotomy (mean difference, 9.7 degrees [95% CI, 3.7 to 16]) and collagenase injection (mean difference, 6.0 degrees [95% CI, 0.1 to 12]), and fewer retreatments. No between-group differences were observed in adjacent untreated or all untreated fingers. Younger age at treatment, smoking, dominantly affected proximal interphalangeal joint, and involvement of the little finger were associated with increased risk of progression or retreatment.
conclusionsSurgery offers more durable results in treated fingers compared with percutaneous methods, although progression and retreatment rates in untreated fingers are similar across all treatment groups. Patients at higher risk for progression (ie, young smokers with affected little fingers) may benefit most from surgery.
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