Evidence map›Paper›PMID 41334969›Full record

Observational studyAmerican journal of hematology2026

Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia.

Pablo Bartolucci, Étienne Audureau, Vincent Audard, Frédéric Galactéros, Guillaume Lettre, Charmaine Anthony, Olufolake Egbujo, Jin Han, Maria Armila Ruiz, James P Lash and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pablo BartolucciHôpital Henri Mondor Assistance Publique des Hôpitaux de Paris (AP-HP), Univ Paris Est-Créteil, Créteil, France.
Étienne AudureauHôpital Henri Mondor Assistance Publique des Hôpitaux de Paris (AP-HP), Univ Paris Est-Créteil, Créteil, France.
Vincent AudardNephrology and Transplantation Department, Henri Mondor University Hospital, APHP, Institut Mondor de Recherche Biomédicale (IMRB), Univ Paris Est-Créteil, Institut National de la Santé et de la Recherche Médicale (INSERM) U955, Créteil, France.
Frédéric GalactérosRed Cell Genetic Disease Unit, Hôpital Henri-Mondor, AP-HP, Université Paris Est, Créteil, France.
Guillaume LettreDepartment of Medicine, Université de Montréal, Montreal, Québec, Canada.ORCID 0000-0002-7740-3399
Charmaine AnthonyNovartis Global Health, East Hanover, New Jersey, USA.
Olufolake EgbujoNovartis Global Health, East Hanover, New Jersey, USA.
Jin HanDepartment of Pharmacy Practice, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0662-006X
Maria Armila RuizDivision of Hematology & Oncology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0003-1190-4219
James P LashDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.
Victor R GordeukDivision of Hematology & Oncology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0003-4725-7295
Xu ZhangDivision of Hematology & Oncology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0002-7732-1385
Santosh L SarafDivision of Hematology & Oncology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0002-8584-4194

Funding

Pathways of Cell-Free Hemoglobin in Sickle Cell NephropathyR01HL153161 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARAF, SANTOSH · 2020 to 2024
$2.0M
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using SGLT2 InhibitorsR01HL180499 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Santosh Saraf, Anand Srivastava · 2025 to 2026
$1.5M
Mentoring & Patient-Oriented Research in Sickle Cell-Related Kidney DiseaseK24HL177273 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Santosh Saraf · 2025 to 2026
$274k
NHLBI NIH HHS K24 HL-177273NHLBI NIH HHS K24 HL177273NHLBI NIH HHS R01 HL-153161NHLBI NIH HHS R01 HL153161NHLBI NIH HHS R01 HL180499Novartis
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is common and a major contributor to increased morbidity and early mortality in people with sickle cell anemia (SCA). Urine albumin-to-creatinine ratio (uACR) is recommended to identify patients with SCA-related CKD but its utility in predicting long-term kidney dysfunction remains unclear in this patient population. In two independent, longitudinal cohorts of patients with hemoglobin SS or Sβ

Indexed as

AlbuminuriaAnemia, Sickle CellKidneyRenal Insufficiency, ChronicAdultCreatinineFemaleFollow-Up StudiesFranceGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsSmokingCreatininealbuminuriakidneysickle cell diseasetobacco smoking

Identifiers

PMID41334969
PMCPMC12766365

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.