Evidence map›Paper›PMID 41334932›Full record

ArticleMicrobiology spectrum2026

Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens.

Ramesh Rijal, Richard H Gomer

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ramesh RijalSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi, USA.ORCID 0000-0003-0498-1064
Richard H GomerDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0003-2361-4307

Funding

Elucidation of a Eukaryotic Chemorepulsion MechanismR35GM139486 · NIGMS · TEXAS A&M UNIVERSITY · PI Richard H Gomer · 2021 to 2026
$2.3M
NIGMS NIH HHS R35 GM139486NIH HHS GM139486
6 · The paper itself

Abstract

After ingestion into macrophage phagosomes, some bacterial pathogens such as IMPORTANCE: Human macrophages engulf bacteria into phagosomes, which then fuse with lysosomes to kill the bacteria. However, after engulfment, pathogenic bacteria such as

Indexed as

Host-Pathogen InteractionsMacrophagesAnimalsDictyosteliumFemaleHumansLegionella pneumophilaListeria monocytogenesMaleMycobacterium tuberculosisPhagosomesPolyphosphatesPolyphosphateshost-directed therapieshost-pathogen interactionsintracellular pathogensmacrophage signaling pathwayspolyphosphate signaling

Identifiers

PMID41334932
PMCPMC12772234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.