ArticleJournal of the American Heart Association2025
Influence of Chronic Kidney Disease on the Relationship Between Menopausal Status and Major Cardiovascular Disease in Women.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sex and gender in cardiovascular-kidney-metabolic health: strengthening the evidence.Nature reviews. Nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is associated with early menopause, and thereby reduced endogenous estrogen exposure (EEE) and elevated risk of cardiovascular disease (CVD).
methodsIncluded were 138 154 naturally menopausal and 63 542 nonmenopausal women from the UK Biobank. To reflect cumulative EEE, duration of EEE was estimated as the time interval between age at menarche and current age (for nonmenopausal women) or age at menopause (for menopausal women). The relationship of menopausal status with incident CVD were assessed by CKD status, further considering cumulative EEE.
resultsMenopausal and nonmenopausal women had a comparable risk of CVD after accounting for age. Menopausal status interacted with CKD on risk of CVD (
conclusionsThe association of menopausal status with risk of CVD appears to be varied by CKD status and further influenced by cumulative exposure to endogenous estrogen. These findings may have implications for more individualized CVD risk stratification and prevention in menopausal women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.