ArticleJournal of the American Heart Association2025
Sex-Based Differences in Long-Term Outcomes of Patients With Ascending Aortic Dilation.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
backgroundThoracic ascending aortopathy (AA) is often asymptomatic and incidentally diagnosed, with surgical replacement recommended once it becomes aneurysmal. We report sex-based characteristics and long-term outcomes of patients with AA.
methodsThis study analyzed 14 244 patients (21.1% women) with unrepaired AA (≥4 cm) diagnosed via echocardiography from 2010 to 2023, excluding those with acute aortic dissection/rupture at presentation (n=1179). Baseline data, including height-indexed measurements (ascending aortic area height index and cross-sectional area to height ratio), were collected. AA surgery and rates of aortic dissection/rupture during follow-up were recorded. Cox proportional hazards and Kaplan-Meier survival analysis were performed for all-cause mortality.
resultsWomen were older (63.6 versus 62.3 years) and had fewer comorbidities, including hypertension, diabetes, coronary artery disease, and dyslipidemia (all
conclusionsDespite fewer comorbidities and higher surgical rates, women with AA had worse long-term survival. Sex-specific thresholds for AA surgery may warrant consideration.
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