In one paragraphArticle in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
19 authors.
Eleni ManetaUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0001-5011-3036 Christos P KyriakopoulosUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0001-9415-1245 Srinivasan BeddhuDivision of Nephrology and Hypertension, Department of Internal Medicine, Spencer Fox Eccles School of Medicine University of Utah Salt Lake City UT USA.ORCID 0000-0002-3312-315X Sydney HartsellDivision of Nephrology and Hypertension, Department of Internal Medicine, Spencer Fox Eccles School of Medicine University of Utah Salt Lake City UT USA.ORCID 0000-0001-7328-3732 Fred WeltUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0003-1802-0491 Eleni TseliouUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0002-9350-2282 Thomas HanffUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0003-3096-1227 Marisca NelsonUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0009-0001-9707-7447 Konstantinos SiderisUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0009-0007-9369-0782 Ioannis KyriakoulisUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0003-2970-088X Jake GoldsteinUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.
Taylor MendenhallUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0009-0009-1546-2156 Amrit DeolUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0009-0000-7384-8713 Rami AlharethiUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0002-2095-1431 Craig SelzmanUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0001-9218-4764 Stavros DrakosUtah Cardiac Recovery (UCAR) and Utah Transplant Affiliated Hospitals (U.T.A.H) Cardiac Transplant Program University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA.ORCID 0000-0002-1223-327X Funding
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6MMechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Mitral RegurgitationR01HL166513 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos · 2023 to 2026
$2.4MClinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9MCellular Remodeling in Heart Failure and after LVAD UnloadingR01HL132067 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE, SACHSE, FRANK BERND · 2017 to 2020
$1.5MThe Role of Glycosyl Ceramides in Heart Failure and RecoveryK08HL168315 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Eleni Tseliou · 2023 to 2026
$717kBLRD VA I01 BX006306CSRD VA I01 CX002291NHLBI NIH HHS K08 HL168315NHLBI NIH HHS R01 HL132067NHLBI NIH HHS R01 HL135121NHLBI NIH HHS R01 HL166513NHLBI NIH HHS T32 HL007576
6 · The paper itselfAbstract
backgroundWhether preleft ventricular assist device (LVAD) kidney function relates to myocardial recovery and LVAD-related adverse events remains uncertain. We evaluated the association of baseline estimated glomerular filtration rate (eGFR) with recovery and adverse events after LVAD implantation.
methodsWe studied participants who underwent LVAD implantation between 2008 and 2021 at any of the 3 institutions comprising the Utah Cardiac Recovery Program. eGFR at implant was categorized as <60 versus ≥60 mL/min per 1.73 m
resultsAmong 385 patients (mean age 56 years, 84% men, 44% ischemic cardiomyopathy), 50 (13%) achieved recovery. Median time to echocardiogram with maximum LV ejection fraction was 120 (IQR, 71-199) days. Preimplant eGFR<60 versus ≥60 mL/min per 1.73 m
conclusionsPre-LVAD low eGFR was not associated with lower rates of myocardial recovery. As the population of patients with concomitant advanced heart failure and cardiorenal syndrome continues to grow, these findings may help guide the management of these challenging patients.
Indexed as
Glomerular Filtration RateHeart-Assist DevicesHeart FailureKidneyVentricular Function, LeftAgedFemaleHumansMaleMiddle AgedRecovery of FunctionRetrospective StudiesRisk FactorsStroke VolumeTime FactorsTreatment Outcomeglomerular filtration ratekidney functionleft ventricular assist devicemyocardial recovery
Identifiers
PMID41334734
PMCPMC12826901
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