Evidence map›Paper›PMID 41334642›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2025

Optimising oncologic outcomes in pT3 glottic cancers treated by transoral laser microsurgery: the impact of adjuvant treatment.

Aurora Pinacoli, Laura Ruiz-Sevilla, Claudio Sampieri, Paolo Bosio, Filippo Marchi, Gabriele Zigliani, Francesca Del Bon, Giorgio Peretti, Isabel Vilaseca, Cesare Piazza

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Glottic tumours involving the anterior vs posterior paraglottic space have different prognosis. Opportunity for refinement of the TNM 8Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
  2. Review
  3. Is there a role for adjuvant radiotherapy after partial laryngectomy? A propensity score matched analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Observational
  4. Margin burden and postoperative management after transoral laser microsurgery for laryngeal glottic squamous cell carcinoma: a multicentre retrospective study on 1216 patients.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aurora PinacoliUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Laura Ruiz-SevillaDepartment of Otorhinolaryngology, Hospital Universitari Joan XXIII, Tarragona, Spain.
Claudio SampieriFunctional Unit of Head and Neck Tumors, Hospital Clinic, Barcelona, Spain.
Paolo BosioUnit of Otorhinolaryngology, ASST Bergamo Est, Seriate, Italy.
Filippo MarchiUnit of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Gabriele ZiglianiUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Francesca Del BonUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Giorgio PerettiUnit of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Isabel VilasecaFunctional Unit of Head and Neck Tumors, Hospital Clinic, Barcelona, Spain.
Cesare PiazzaUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The treatment strategy for cT3 glottic squamous cell carcinoma (SCC) is far from being standardised, and the role of adjuvant treatment(s) is not clearly defined. This study assessed the impact of adjuvant (chemo-)radiotherapy ([C]RT) for patients with pT3 glottic SCC treated by transoral carbon dioxide laser microsurgery (CO Methods: A multicentric retrospective study was conducted at 3 referral hospitals, including patients with pT3 glottic SCC treated from January 2010 to October 2023. Demographic, clinical, and histopathological data were collected, together with data on surgery, postoperative functional performance, adjuvant treatment(s) with (C)RT, and complications. Five- and 10-year overall (OS), disease-specific (DSS), disease-free (DFS), and total laryngectomy free survivals (TLFS) were estimated by Kaplan-Meier curves. Uni- and multivariate Cox proportional hazards regression models were used to determine independent risk factors for survivals. Results: One hundred and forty-one patients treated with CO Conclusions: This study suggests that adjuvant treatment with (C)RT has a positive impact on DFS for pT3 glottic SCC treated by CO

Indexed as

Carcinoma, Squamous CellGlottisLaryngeal NeoplasmsLaser TherapyMicrosurgeryAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingRadiotherapy, AdjuvantRetrospective StudiesTreatment Outcomeadjuvant treatmentcancerCOglottislarynxradiotherapyT3transoral microsurgery

Identifiers

PMID41334642
PMCPMC12673943

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.