Evidence map›Paper›PMID 41334638›Full record

Trial reportChinese medical journal2026

Stool-based methylated syndecan-2 test and fecal immunochemical test for advanced colorectal neoplasia screening in the Chinese population: A multicenter randomized noncomparative study.

Yufeng Chen, Jiaxin Li, Kai Gu, Kefeng Ding, Pengzhe Qin, Zhengcun Pei, Yangming Gong, Dong Xu, Yingru Liang, Dong Yang and 14 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chinese medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04221854 (Stool-based SDC2 DNA Methylation Test vs. Fecal Immunochemical Test on the Detection of Colorectal Advanced Adenomatous Polyps and Cancer in Chinese Population), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04221854 naunknown statusnot on this map

Stool-based SDC2 DNA Methylation Test vs. Fecal Immunochemical Test on the Detection of Colorectal Advanced Adenomatous Polyps and Cancer in Chinese Population: A Multi-central Randomized Clinical Trial

TypeinterventionalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2020 to 2021Enrolled50,000ConditionsColorectal Cancer, Colorectal Adenomatous Polyp, ScreeningArmsStool-based SDC2 DNA methylation test, Fecal immunochemical test
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yufeng ChenDepartment of General Surgery (Colorectal Surgery) and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Jiaxin LiDepartment of General Surgery, Tianjin Third Central Hospital, Tianjin 300170, China.
Kai GuShanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China.
Kefeng DingDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Pengzhe QinGuangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong 510440, China.
Zhengcun PeiMedical College, Tianjin University, Tianjin 300072, China.
Yangming GongShanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China.
Dong XuDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Yingru LiangGuangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong 510440, China.
Dong YangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China.
Jianming DouShanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China.
Yanqin HuangDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Jiancong HuDepartment of Gastrointestinal Endoscopy and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Pan WuDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Shuyi ZhangDepartment of Endoscopy, Tianjin Union Medical Center, Tianjin 300121, China.
Wenrui WangDepartment of Science and Education, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Lishuo ShiCenter for Clinical Research, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Qing LiuCancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.
Chujun LiDepartment of Gastrointestinal Endoscopy and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Wen LiDepartment of Endoscopy, Tianjin Union Medical Center, Tianjin 300121, China.
Ximo WangMedical College, Tianjin University, Tianjin 300072, China.
Ping LanDepartment of General Surgery (Colorectal Surgery) and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Boheng LiangGuangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong 510440, China.
Xiaosheng HeDepartment of General Surgery (Colorectal Surgery) and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is among the most prevalent malignancies, with an increasing incidence in China, posing increasing challenges to current screening strategies. This study aimed to evaluate the feasibility of a screening strategy based on the stool-based methylated Syndecan-2 gene (mSDC2) test for detecting advanced colorectal neoplasia in the Chinese population.

methodsIn this multicenter randomized study, participants aged 45-80 years and identified through community screening were randomized to take either the mSDC2 test or a fecal immunochemical test (FIT), and those with positive results were referred for colonoscopy between 2020 and 2022. The primary outcome was the detection rate of advanced colorectal neoplasia, including advanced adenoma, advanced serrated polyps, and CRC. The secondary outcome was adherence to colonoscopy. Univariable and multivariable logistic regression analyses were conducted to evaluate colonoscopy adherence among participants with positive stool-based test results.

resultsA total of 44,475 eligible participants were enrolled from 189 communities (93 in the mSDC2 test group and 96 in the FIT group). In the mSDC2 test group ( n = 21,854), the detection rate of advanced neoplasia was 0.53% ( n = 115), including 93 (0.43%) advanced adenomas, 8 (0.04%) advanced serrated polyps, and 17 (0.08%) CRC cases. In the FIT group ( n = 22,621), the detection rate of advanced neoplasia was 0.47% ( n = 106), including 71 (0.31%) advanced adenomas, 9 (0.04%) advanced serrated polyps, and 29 (0.13%) CRC cases. In addition, adherence to colonoscopy was greater in the mSDC2 test group (35.6% vs. 26.4%; odds ratio: 1.59, 95% confidence interval: 1.36-1.87; P <0.001).

conclusionsThis study revealed the effectiveness of the mSDC2 test and FIT in detecting advanced colorectal neoplasia in a large Chinese population in a real-world setting, and indicated a possible improvement in adherence to colonoscopy for the mSDC2 test. Further studies with improved comparability and longer follow-up are warranted to clarify its clinical utility. REGISTRATION: ClinicalTrials.gov , No. NCT04221854.

Indexed as

Colorectal NeoplasmsFecesSyndecan-2AgedAged, 80 and overColonoscopyEarly Detection of CancerEast Asian PeopleFemaleHumansMaleMiddle AgedOccult BloodSyndecan-2ColonoscopyColorectal neoplasmsEarly detection of cancerFecal immunochemical testPatient complianceSyndecans

Identifiers

PMID41334638
PMCPMC13626678

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.