Evidence map›Paper›PMID 41334602›Full record

SynthesisAsian cardiovascular & thoracic annals2026

Optimization in long-term survival after multiple arterial grafting in coronary artery bypass: A systematic review and meta-analysis.

Aqyl Hanif Abdillah, Agustian Sofian, Auzan Hakim Agustian, Azzahra Fadhilah, Annisa Fatharani

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Asian cardiovascular & thoracic annals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aqyl Hanif AbdillahFaculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.ORCID 0009-0000-3089-8884
Agustian SofianDepartment of Thoracic and Cardiovascular Surgery, Pertamina Pusat Hospital, South Jakarta, Indonesia.
Auzan Hakim AgustianFaculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.ORCID 0009-0006-7121-3240
Azzahra FadhilahFaculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0009-0004-4986-1896
Annisa FatharaniFaculty of Medicine and Life Sciences, King's College London, London, UK.ORCID 0009-0007-1667-7429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionSurgical revascularization through coronary artery bypass is a widely accepted approach for treating diseases affecting multiple coronary vessels. While the standard approach uses a single arterial graft combined with vein grafts, using numerous arterial grafts may improve long-term outcomes. Although supported by observational data and guideline recommendations, the broader adoption of multiple arterial grafting has been limited due to a lack of definitive randomized trial evidence and uncertainties in specific patient subgroups.MethodsA systematic review and meta-analysis were conducted to compare long-term survival in patients receiving multiple versus single arterial grafts during coronary artery bypass surgery. Twenty-seven studies (including one randomized trial) involving more than one million patients were included. The primary outcome was long-term all-cause mortality. Hazard ratios with 95% confidence intervals were pooled using a random-effects model. Subgroup analyses were performed based on age, sex, diabetes status, graft conduit type, extent of arterial revascularization, and left ventricular function. Meta-regression examined the impact of patient characteristics.ResultsMultiple arterial grafting was associated with a significant reduction in long-term mortality compared to single arterial grafting. The pooled hazard ratio indicated an approximate 20% relative reduction in mortality. This survival benefit was consistent across all evaluated subgroups. Meta-regression did not identify any patient characteristic that significantly altered the benefit of multiple arterial grafting. No significant publication bias was detected.ConclusionMultiple arterial grafting is associated with improved long-term survival in coronary artery bypass surgery. These findings support the broader implementation of this strategy in suitable patients while emphasizing the need for individualized surgical decision-making.

Indexed as

Coronary Artery BypassCoronary Artery DiseaseAgedFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeCABGconduit selectionmultiple arterial graftingsingle arterial graftingsurvival

Identifiers

PMID41334602
PMCPMC12789258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.