Evidence map›Paper›PMID 41334523›Full record

ReviewMycology2025

Regulation and functions of alternative polyadenylation in fungi.

Lei Zhang, Xiaoling Deng, Wenshuai Ma, Tianjiao Zhou, Chuan Xu

Abstract readReview
In one paragraph

Review in Mycology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei ZhangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Xiaoling DengBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Wenshuai MaBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Tianjiao ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chuan XuBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative polyadenylation (APA) has been implicated in regulating transcriptome diversity and gene expression by significantly altering mRNA abundance, stability, localisation, and translation. Understanding the comprehensive landscape of APA can provide valuable insights into the complexity of gene regulation. In this review, we first outline the critical factors and mechanisms for the selection of PAS. Then, we summarise the experimental as well as the bioinformatic technologies for studying APA. In addition, we review and discuss current studies on fungi, aiming to highlight the role of APA in various biological processes, including growth and development, metabolism, responses to stress, and potential contribution towards virulence during host infection. Finally, we propose key questions along with perspectives for future research on APA in fungi. With more in-depth studies like comparative transcriptomic analyses, genome-wide poly(A) site mapping throughout the fungal kingdom, additional signatures and functions of APA will be uncovered, and its diverse roles will gradually come into focus.

Indexed as

Alternative polyadenylationfunctionsfungigene regulationtranscription

Identifiers

PMID41334523
PMCPMC12667328

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.