ReviewMycology2025
Deciphering the role of mitochondria in human fungal drug resistance.
Review in Mycology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Integrated omics analyses reveal natamycin disrupts oxidative phosphorylation pathways in Magnaporthe oryzae.BMC plant biology · 2026Article
- Monothiol glutaredoxins in microbial iron metabolism: From iron-sulfur cluster trafficking to iron-dependent regulation.Advances in microbial physiology · 2026Review
- Mitochondrial characteristics of echinocandin tolerance and resistance inFrontiers in microbiology · 2026Article
- The kinases Hsl101 and Urk1 regulate metabolism of Cryptococcus neoformans.Scientific reports · 2025Article
- The kinase Bud32 regulates iron homeostasis in fungal pathogenFrontiers in immunology · 2025Article
- AI in fungal drug development: opportunities, challenges, and future outlook.Frontiers in cellular and infection microbiology · 2025Review
- Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation inFrontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As pathogenic fungi increasingly threaten public health, particularly in immunocompromised populations, understanding the mechanisms behind fungal drug resistance has become critical. This review focuses on the pivotal role of mitochondria in this process. Evidence indicates that mitochondria are essential not only for cellular energy metabolism and responses to oxidative stress but also for significantly influencing the expression and activity of drug efflux pumps, which facilitate the expulsion of antifungal agents. Moreover, the intricate roles of mitochondria in iron homoeostasis and calcium signalling are closely linked to the development of drug resistance in fungi. By elucidating these mechanisms, we can identify potential therapeutic targets and pave the way for more effective strategies to combat resistant fungal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.