Evidence map›Paper›PMID 41334493›Full record

ArticleJSLS : Journal of the Society of Laparoendoscopic Surgeons

Indocyanine Green Fluorescence to Assess Parathyroid Glands Function during MIVAT.

Paolo Gisonni, Casimiro Nigro, Serena Elisa Tempera, Giulia Salvi, Luca Sessa, Rosa Maria Paragliola, Pietro Princi

Abstract read
In one paragraph

Article in JSLS : Journal of the Society of Laparoendoscopic Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paolo GisonniUnicamillus International Medical University, Rome, Italy. (Drs. Gisonni, Sessa, Paragliola, and Princi).
Casimiro NigroUOC Multifunctional Center of Endocrine Surgery, Cristo Re General Hospital, Rome, Italy. (Drs. Nigro, Tempera, Salvi, and Princi).
Serena Elisa TemperaUOC Multifunctional Center of Endocrine Surgery, Cristo Re General Hospital, Rome, Italy. (Drs. Nigro, Tempera, Salvi, and Princi).
Giulia SalviUOC Multifunctional Center of Endocrine Surgery, Cristo Re General Hospital, Rome, Italy. (Drs. Nigro, Tempera, Salvi, and Princi).
Luca SessaUnicamillus International Medical University, Rome, Italy. (Drs. Gisonni, Sessa, Paragliola, and Princi).
Rosa Maria ParagliolaUnicamillus International Medical University, Rome, Italy. (Drs. Gisonni, Sessa, Paragliola, and Princi).
Pietro PrinciUnicamillus International Medical University, Rome, Italy. (Drs. Gisonni, Sessa, Paragliola, and Princi).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative hypoparathyroidism is the most common complication of total thyroidectomy, often resulting from injury or devascularization of the parathyroid glands. Objective: Indocyanine green fluorescence (ICG) technique has been applied in the last 10 years in different kinds of surgery including colorectal, oncological lymph node and endocrine surgery. Minimally invasive thyroidectomy, introduced more than 25 years ago, is a valid surgical option for selected benign and malignant thyroid disease with advantages in terms of cosmetic results and postoperative pain. Aim of this study is to evaluate the feasibility and safety of ICG during minimally invasive thyroidectomy to assess and predict parathyroid gland perfusion and guide preservation. Methods: We report the initial experience in our center of ICG during minimally invasive video-assisted total thyroidectomy in a case series of 9 patients, using the Striker System® to assess parathyroid perfusion and guide preservation. Demographic and surgical data were registered with special attention to hypoparathyroidism. Results: All patients underwent standard minimally invasive video-assisted total thyroidectomy; a standardized dose of ICG was administered intravenously. Real-time near-infrared imaging allowed for clear visualization of parathyroid vascularization, enabling the preservation of well-perfused glands and the auto transplantation of those removed into the sternothyroid muscle. Postoperative assessments, including serial measurements of serum calcium and parathyroid hormone levels, revealed a transient drop in two patients with overall correspondence to indocyanine green evaluation. Conclusion: These findings suggest that ICG angiographic imaging is a valuable adjunct in thyroid surgery, potentially reducing the risk of hypocalcemia by optimizing parathyroid preservation. Further studies are needed to standardize the technique and the evaluation score to confirm preliminary results on definitive hypoparathyroidism.

Indexed as

HypoparathyroidismIndocyanine GreenParathyroid GlandsThyroidectomyVideo-Assisted SurgeryAdultAgedColoring AgentsFeasibility StudiesFemaleFluorescenceHumansMaleMiddle AgedPostoperative ComplicationsColoring AgentsIndocyanine GreenHypoparathyroidismIndocyanine green fluorescenceMinimally invasive video-assisted thyroidectomyNear-infrared fluorescence imagingTotal thyroidectomy

Identifiers

PMID41334493
PMCPMC12668367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.